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Informationen zum Autor Professor Clive P. Page, BSc PhD OBE HonFBPhS is a Professor of Pharmacology, King’s College London and Director of the Sackler Institute of Pulmonary Pharmacology, King’s College London. Clive’s main research interests are in the pharmacology of inflammation and respiratory disease and he has published over 250 scientific papers. Clive was the co-founder and previous Chairman of the Board of Verona Pharma plc, an AIM listed Company developing new drugs for the treatment of Respiratory Diseases. He is a Non Executive Director of and on boards of several companies. He was awarded the Society of Biology President’s Medal in 2012 for an outstanding contribution to the life sciences over the previous year. He is a Fellow of the Royal Society of Biology and an Honorary Fellow and President Elect of the British Pharmacological Society. In 2017, Clive was awarded an OBE for Services to Pharmacology. Klappentext The aims of the book are to provide an authoritative reference for academic and clinical research scientists and teachers with interests in immunology, inflammation and pharmacology and we are grateful to all the contributors who have presented the most up-to-date information available. We believe that the book will stimulate the concept of immunopharmacology as a true discipline if pharmacology with exciting avenues to be rapidly explored and which should lead to the alleviation of the destructive inflammatory arthritides. Zusammenfassung Covers various aspects of immunopharmacology. This work covers each of the major cell types and classes of inflammatory responses. It covers different classes of diseases as well as the drugs under development. Inhaltsverzeichnis Contributors. Series Preface. Preface. Introduction. The Background to Autoimmunity, W.M. Williams, M.R. Ehrenstein, and D.A. Isenberg . Immunological Tolerance and its Implications for Autoimmunity, N.A. Mitchison . Peptide Blockade and Antigen-specific Modulation of Autoimmune Disease, D.C. Wraith . Monoclonal Antibody Therapy of Experimental Arthritis - Comparison with Cyclosparin A for Elucidating Cellular and Molecular Disease Mechanisms, M.E.J. Billingham . Anti-CD4 and Other Antibodies to Cell Surface Antigens for Therapy, F. Emmrich, H. Schulze-Koops, and G. Burmester . Are Imbalances in Cytokine Function of Importance in the Pathogenesis of Rheumatoid Arthritis?, M. Feldmann, F.M. Brennan, E.R. Abney, A. Hales, Y. Chernajovsky, P. Katsikis, A. Corcoran, C. Haworth, A. Cope, D. Gibbons, C.Q. Chu, M. Field, B. Deleuran, R.O. Williams, and R.N. Maini . Naturally Occuring Inhibitors of Cytokines, W.P. Arend and J.-M. Dayer . Soluble Immunopeptides in Inflammatory Arthritis, J.A. Symons and G.W. Duff . Inflammatory Reactions in Arthritis, H.-G. Fassbender . Connective Tissue Destruction in Rheumatoid Arthritis: Therapeutic Potential of Selective Metalloproteinase Inhibitors, B. Henderson and S. Blake . Lysosomal Cysteine Endopeptidases in the Degradation of Cartilage and Bone, D.J. Buttle . Glossary. Key to Illustrations. Index....
