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Informationen zum Autor Peter Gahan and R. Swaminathan are the authors of Annals of the New York Academy of Sciences, Volume 1137, Circulating Nucleic Acids in Plasma and Serum V, published by Wiley. Klappentext An accurate, inexpensive, and noninvasive method for the early diagnosis of cancer has been something of a holy grail among cancer researchers, but until recently a method meeting all three criteria has been elusive. Nucleic acids were first discovered in circulation in 1948, but it was not until the 1960s and 70s that patients with autoimmune disease and cancer were discovered to have higher levels of circulating DNA than were detected in in healthy persons. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas . ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( www.nyas.org ). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung DNA and RNA fractions have been isolated from whole blood! serum! plasma! the surface of blood cells! and urine from both healthy persons and patients. Specific fragments have been identified as being related to particular disorders! for example! diabetes! cancer! myocardial infarction! and stroke. Inhaltsverzeichnis Preface: Peter B. Gahan and R. Swaminathan. Circulating Nucleic Acids in Plasma and Serum: Recent Developments: Peter B. Gahan and R. Swaminathan. Part I. Basic Research:. 1. Metabolic DNA as the Origin of Spontaneously Released DNA?: Peter Gahan, Philippe Anker, and Maurice Stroun. 2. Circulating DNA: Its Origin and Fluctuation: Maniesh van der Vaart and Piet J. Pretorius. 3. The Origin of Elevated Levels of Circulating DNA in Blood Plasma of Premature Newborns: N. O. Tuaeva, Z.I. Abramova and V. V. Sofronov. 4. The Effect of Protein Transport Inhibitors on the Production of Extracellular DNA: Evgeniy S. Morozkin, Tatyana I. Babochkina, Valentin V. Vlassov, and Pavel P. Laktionov. 5. Binding and Penetration of Methylated DNA into Primary and Transformed Human Cells: Tatyana E. Skvortsova, Valentin V. Vlassov, and Pavel P. Laktionov. 6. Extracellular DNA Fragments: Factors of Stress Signalling between X-irradiated and Non-irradiated Human Lymphocytes: Aleksei V. Ermakov, Svetlana V. Kostyuk, Marina S. Konkova, Natalya A. Egolina, Elena M. Malinovskaya, and Natalya N. Veiko. 7. Isolation and Sequencing of Short Cell-Surface-Bound DNA: Vera S. Mal'shakova, Dmitry V. Pyshnyi, Alexander A. Bondar, Valentin V. Vlassov, and Pavel P. Laktionov. 8. Extracellular RNA Spontaneously Internalized by Human Cells Undergo Deamination of Adenosines: Elena V. Kuligina, Oksana V. Vratskih, Dmitry V. Semenov, Vera A. Matveea, and Vladimir A. Richter. 9. Circulating Nucleic Acids in the Assessment of Endogenous Growth Hormone Production: H. Thakkar, A.N. Butt, J. Powrie, R. Holt, and R. Swaminathan. 10. The Involvement of Different Mobile Line Copies of Blood Plasma and Extrachromosomal DNA of Liver Cells in Systemic Adaptive Response: Sophiya S. Sherlina and Viktor G. Vladimirov. Part II. Methodology:. 11. Transrenal Nucleic Acids from Proof-of-Principle to Clinical Tests: Problems and Solutions: Hovsep S. Melkonyan, W. John Feaver, Erik Meyer, Vladimir Scheinker, Eugene M. Shekhtman, Zhenghan Xin, and Samuil R. Umansky. 12. Removal of High Molecular Weight DNA by Carboxylated Magnetic Beads Enhances the Detection of Mutated K-ras DNA in Urine: Ying-Hsiu Su, Janet Song, Zhili Wang, Xiao-He Wang, Mengjun Wang, Dean E. Brenner, and Tim...
