Read more
Klappentext A comprehensive explanation of the extraordinary benefits of pneumococcal conjugate vaccines, arguably the greatest public health achivement of the new millennium. This book describes the development of the vaccines, their remarkable impact on respiratory infections, and the vaccines wider impact. Zusammenfassung Show how to monitor and measure the effects of pneumococcal conjugate vaccine introduction. This title discusses the world-wide potential of the vaccines. It details the impact of vaccination on childhood respiratory disease! including antibiotic resistance! and makes clear the biology of the pneumococcus in relation to disease. Inhaltsverzeichnis Table of ContentsDedication: Robert Austrian! M.D.! Jeffrey N. Weiser! M.D.I. HISTORY1 The History of Pneumococcal Disease! Barry M. Gray and Daniel M. Musher2 History of Pneumococcal Immunization! P. Helena Mäkelä and Jay C. ButlerII. BIOLOGICAL BASIS3 Genetics! Biosynthesis! and Chemistry of Pneumococcal Capsular Polysaccharides! Janet Yother! Stephen D. Bentley! and John P. Hennessey! Jr.4 Animal Models of Invasive Pneumococcal Disease! David E. Briles! Susan K. Hollingshead! and Ingileif Jonsdottir5 Animal Models of Pneumococcal Colonization! Richard Malley and Jeffrey N. Weiser6 The Immunobiology of Polysaccharide and Conjugate Vaccines! David Goldblatt! Tracy Assari! and Clifford Snapper7 Interactions of Streptococcus pneumoniae with Complement Proteins! Margaret K. HostetterIII. CLINICAL DISEASE AND EPIDEMIOLOGY8 Epidemiology! Diagnosis! and Treatment of Serious Pneumococcal Infections in Children! Shabir A. Madhi and Stephen I. Pelton9 Pneumococcal Pneumonia in Adults: Epidemiology! Clinical Features! Diagnosis! and Therapy! Jeffrey B. Rubins! David Boulware! and Edward N. Janoff10 Pneumococcal Serotype Epidemiology! William P. Hausdorff! Angela B. Brueggemann! Jill G. Hackell! and J. Anthony G. ScottIV. MANUFACTURING AND PRODUCT RELEASE ISSUES11 Conjugation Chemistry! Andrew Lees! Velupillai Puvanesarajah! and Carl E. Frasch12 Pneumococcal Vaccines: Manufacture and Quality Control for Product Release! Milan S. Blake13 Licensing of Pneumococcal Conjugate Vaccines for Children and Adults: Regulatory Perspective from the European Medicines Agency and the U.S. Food and Drug Administration! Marion F. Gruber! Douglas Pratt! and Manfred HaaseV. IMMUNOGENICITY14 Quantitation of Anti-Pneumococcal Capsular Antibody in Ligand-Binding Assays! Dace V. Madore! Sally A. Quataert! and Merja Vakevainen15 Functional Assays for Pneumococcal Antibody! Moon H. Nahm and Sandra Romero-Steiner16 Immunogenicity and Reactogenicity of Pneumococcal Conjugate Vaccines in Infants and Children! Helena Käyhty! Stephen Lockhart! and Lode Schuerman17 Immunogenicity and Safety in Adults! Lisa A. Jackson and George R. Siber18 Immunogenicity in High-Risk and Immunocompromised Children and Adults! Neil French! Sharon Nachman! and Stephen I. PeltonVI. EFFICACY AND SAFETY19 Nasopharyngeal Carriage! Katherine L. O'Brien! Ron Dagan! and P. Helena Mäkelä20 Acute Otitis Media and Its Sequelae! Terhi Kilpi and Lode Schuerman21 Meta-Analysis of the Efficacy of Conjugate Vaccines against Invasive Pneumococcal Disease! Keith P. Klugman! Felicity Cutts! Richard A. Adegbola! Steven Black! Shabir A. Madhi! Katherine L. O'Brien! Mathuram Santosham! Henry Shinefield! and Jonathan A. C. Sterne22 Efficacy and Safety of Conjugate Pneumococcal Vaccine in the Prevention of Pneumonia! Shabir A. Madhi and Keith P. Klugman23 Establishing Immune Correlates of Protection! Robert C. Kohberger! Jukka Jokinen! and George R. SiberVII. PUBLIC HEALTH IMPACT24 Direct and Indirect Effectiveness and Safety of Pneumococcal Conjugate Vaccine in Practice! Cynthia G. Whitney and Matthew R. Moore25 Impact of Conjugate Pneumococcal Vaccine on Antibiotic Resistance! Ron Dagan and Keith P. Klugman26 Pharmacoeconomic...
