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Zusatztext "Due to the wealth of new information that we have gained over the last 15 years! a new edition is absolutely necessary to keep pace with the study of environmental substances and their effects on reproduction and development ... This book easily leads the pack in the field of research toxicology. For those interested in keeping current in this field! it is a must-have. It is important to note that this book should be on the shelf of any physician-scientist studying the impact of environmental exposures on human health! reproduction! and development."-Doody's Review Service ?"This new edition of the Target Organ Toxicology series is a welcome addition to the series and! as with the previous two editions! it has brought together the leading authorities in the field to provide an authoritative text on the increasingly important topic of reproductive toxicology. The breadth of the topics covered is truly impressive and while there is continuity with the previous two editions! this third edition covers areas which will undoubtedly be a surprise to some! as it was to this reviewer."-The British Toxicology Society Newsletter Informationen zum Autor Robert W. Kapp, Rochelle W. Tyl Klappentext Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology's contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research.This ground-breaking resource includes:New and important critical mechanistic topics such as epigenetics and omicsThe first significant compilation of epigenetic mechanismsAn in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproductionNew guidelines with respect to the latest research applications in the field Zusammenfassung Reproductive Toxicology Inhaltsverzeichnis Section I: Normal Reproduction and Development. 1. Biology and Physiology of Fertilization. 2. Normal Development of the Male Reproduction System. 3. Normal Development of the Female Reproduction System. 4. Development of the Mammalian Nervous System. Section II: Regulatory Evaluation of Reproduction. 5. EPA and OECD Perspectives on Reproductive and Developmental Toxicity Testing. 6. FDA and ICH Perspectives on Reproductive and Developmental Toxicity Testing. 7. Reproductive Study Evolution and IND Submissions. Section III: Developmental Toxicity of Systemic Organ Systems. 8. Developmental Immunotoxicity. 9. Developmental Neurotoxicity. 10. Developmental Toxicology of the Respiratory System. 11. Developmental Toxicology of the Renal System. 12. Developmental Toxicology of the Liver. 13. Cardiovascular Development and Malformation. Section IV: Toxicity of the Reproductive Process. 14. Male Reproductive Toxicity. 15. Female Reproductive Toxicity. 16. Toxicity of Pregnant Female Reproductive System. 17. Epigenetic Reproductive Toxicants. 18. Endocrine Disruption Effects on Reproductive Development and Adult Reproduction. 19. Metals and Metal Compounds in Reproductive and Developmental Toxicology. 20. -omics in Reproductive and Developmental Toxicology. ...
