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Klappentext This volume covers contemporary advances in five important areas of pharmacology and medicinal chemistry including: a comprehensive account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis, and other peripheral and central indications; adoc umented survey of semi-synthetic and totally synthetic antibiotics and anti HIV agents and their sites of interaction; inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) developed for the treatment of hypercholesterolemia; and recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action. Inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), required for viral replication, is one of the most attractive targets for HCV infections. Progress and prospects in the design of peptide and non-peptide inhibitors are described here. design and clinical potential of new drug molecules; valuable summaries of structure-activity relationships in topical areas of medicinal chemistry; and extensive references to the biology, medicinal chemistry and clinical aspects of each topic. Caspase inhibitors as anti-inflammatory and antiapoptotic agents, P.P. Graczyk; RNA as a drug target, M.J. Drysdale, et al.; ACAT inhibitors - the search for a novel and effective treatment of hypercholesterolemia and atherosclerosis, D.R. Sliskovic, J.A. Picard, B.R. Krause; growth hormone secretagogues - discovery of small orally active molecules by peptidomimetic strategies, M. Ankersen; inhibitors of hepatitis C virus NS3.4A protease - an overdue line of therapy, R.B. Perni, A.D. Kwong.
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"...a valuable source of reference" --British Medical Journal
"...may the Progress in Medicinal Chemistry series continue its invaluable service..." --Chemistry and Industry
