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Informationen zum Autor Paul O'Higgins began studying medicine at the University of Leeds in 1976. He earned a BSc in Anatomy and developed an interest in primate and human evolution. He returned to complete medical studies, qualifying in 1982. For the next 6 years he pursued his Ph.D. while practicing medicine and lecturing in Anatomy at the University of Leeds. He received his Ph.D. in 1989 and in 1990 was named Senior Lecturer in Anatomy at the University of Western Australia. In 1994 he returned to London where he became a Reader in Anatomy at University College. His focus there is in geometric modelling and comparison of growth in relation to evolution and sexual dimorphism. Martin Cohn obtained a B.A. in Anthropology from the University of Texas at Austin in 1991. From 1991 through 1993, he carried out research on digit reduction in extant and extinct mammals at Kent State University, earning his Master's Degree. In 1993, he began work on a Ph.D. at University College London where he focused on the molecular mechanisms controlling the initiation of limb development and the positioning of limbs along the head-to-tail axis of vertebrate embryos. He moved to the University of Reading in 1997 as a postdoctoral fellow in evolutionary developmental biology. Since 1998 he has been the BBSRC David Phillips Research Fellow at the University of Reading. His current focus is the origin of fin and limb development, and molecular basis limb loss, in vertebrate evolution. Klappentext This book presents a synthesis of the modern approaches to the study of ontogeny and the interpretation of the fossil evidence for human origins. Recent years have seen significant developments in the understanding of the regulation of embryonic pattern formation and skeletal adaptation! and in techniques for the visualizations and analysis of ontogenetic transformations! offering the prospect of understanding the mechanisms underpinning phylogenetic transformation in the skeleton. Advances in developmental biology! molecular genetics! biomechanics! microscopy! imaging and morphometrics are brought to bear on the subject. Key Features* Reviews important hot subject areas* Juxtaposes contributions by developmental biologists and those by evolutionary morphologists* Makes some bold insights; synthesizes development and evolution Zusammenfassung Presents a synthesis of the modern approaches to the study of ontogeny and the interpretation of the fossil evidence for human origins. This book brings advances in developmental biology! molecular genetics! biomechanics! microscopy! imaging and morphometrics. It reviews important hot subject areas. Inhaltsverzeichnis Molecular Control of Vertebrate Limb Development, Evolution, and Congenital Malformations: M.J. Cohn and P.E. Bright , Introduction. Specification and Initiation of Limbs. Limb Identity: Forelimbs or Hindlimbs? Outgrowth and Patterning: Generating Bones from Buds. Hox Genes in Limb Development. Evolution of Tetrapod Limbs. Congenital Limb Anomalies: Linking Malformations to Molecules. Conclusions. Acknowledgments. References. Biomechanical Influences on Skeletal Growth and Development: T. Skerry , Introduction. Functions of the Skeleton. Historical Perspectives of Mechanical Influences on Bone. Quantitative Studies on Effects of Loading on Bone. Responses of Bone Cells to Loading. Conclusions. Acknowledgments. References. The Evolution of Mammalian Morphology: A Developmental Perspective: C.O. Lovejoy, M.J. Cohn and T.D. White , Introduction. Early Patterning of the Limb Skeleton. Functional Integration Within the Limb Bud. Some Implications for the Interpretation of Mammalian Skeletal Evolution. Conclusions. Acknowledgments. References. Development and Patterning of the Cranium: P. Thorogood and T. Schilling ....
