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CANCER A DYSMETHYLATION SYNDROME

English, French · Paperback / Softback

Description

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In this book, the authors suggest that a «dysmethylation syndrome» disrupts essential regulations controlling cellular growth, metabolism and mitosis, and may then cause cancer. Dysmethylations (hyper or hypomethylations) affect not only the expression of genes controlling growth and mitosis, but also the activity of enzymes such as (PP2A) phosphatase, which is assembled after methylation. PP2A limits the action of trophic kinases activated by growth factors or by oncogenes.

In neurones, the syndrome associated to a poor methylation of the phosphatase and other substrates, leads to hyperphosphorylated proteins, as found in Alzheimer's disease. Cancer, Alzheimer's disease may possibly have, like Biermer's anemia, essential links with methylation processes.

Product details

Authors Maurice Israël, Maurice Israel, ISRAEL M, ISRAEL M SCHWARTZ L, Laurent Schwartz, Maurice Israël, Maurice Israël, Laurent Schwartz
Publisher JOHN LIBBEY EUROTEXT EDITIONS
 
Languages English, French
Product format Paperback / Softback
Released 15.10.2005
 
EAN 9782742005970
ISBN 978-2-7420-0597-0
Weight 255 g
Series Médecine sciences. Sélection
Médecine sciences, Sélection
Subject Natural sciences, medicine, IT, technology > Medicine

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