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Skin cancer is the most frequent malignancy in humans and its incidence is still increasing. This situation calls for major efforts to manage the disease. Preventive measures must include reduced UV exposure and an enhanced common awareness of skin lesions. Advanced surgical techniques allow safe removal with excellent cosmetic results. In many cases alternative treatment modalities such as radiotherapy, cryosurgery and photodynamic therapy are applicable. The development of optimal sun screens and UV-protective clothes, new tools for early diagnosis of malignant lesions including videomicroscopy, improved evaluation of biopsy material and new treatment schemes will contribute to better patient care. New developments in therapy including pegylated interferons, cytokine-inducing molecules, monoclonal antibodies and vaccination approaches using peptides, dendritic cells, viruses or nDNA give hope for well-tolerated and efficient treatments.
List of contents
1 Prevention.- Public Education in Skin Cancer World-Wide.- UV Protection and Skin Cancer.- 2 UV Protection by Clothes.- Role of Clothes in Sun Protection.- Sun Protective Clothing: 5 Years of Experience in Australia.- European Standards for Protective Apparel Against UV Radiation.- American Standards for UV-Protective Textiles.- Activities of CIE DIV-6 (Photobiology and Photochemistry) in UV Protection and Clothing.- Comparison of Methods: Determination of UV Protection of Clothing.- Improving UV Protection by Clothing - Recent Developments.- Dress up for Sun Protection/Creation of Public Awareness.- 3 Melanoma Pathogenesis.- The Precursors of Malignant Melanoma.- Interferon-a Sensitivity in Melanoma Cells: Detection of Potential Response Marker Genes.- Molecular Cytogenetics as a Diagnostic Tool for Typing Melanocytic Tumors.- Loss of Heterozygosity and Microsatellite Instability in Acquired Melanocytic Nevi: Towards a Molecular Definition of the Dysplastic Nevus.- Epidemiology.- The Changing Incidence and Mortality of Melanoma in Australia.- Diagnostic.- Why Is Epiluminescence Microscopy Important?.- Sentinel Node Biopsy: Not Only a Staging Tool?.- Therapy.- The Impact of Surgery on the Course of Melanoma.- Perspectives of Pegylated Interferon Use in Dermatological Oncology.- Dendritic Cell Vaccination for the Treatment of Skin Cancer.- Gene-based Immunotherapy of Skin Cancers.- Cytokine-Fusion-Protein-Treatment.- Cytotoxic T-cell Induction in Metastatic Melanoma Patients Undergoing Recombinant Vaccinia Virus-based Immuno-gene Therapy.- Follow-up.- A Rational Approach to the Follow-up of Melanoma Patients.- 4 Epithelial Skin Tumors Therapy.- Micrographic Surgery of Basal Cell Carcinomas of the Head.- Repair of Cutaneous Defects After Skin Cancer Surgery.- Radiotherapy of Skin Tumors.- Photodynamic Therapy and Fluorescence Diagnosis of Skin Cancers..- Intralesional Interferon in Basal Cell Carcinoma: How Does It Work?.- Epithelial Malignancies in Organ Transplant Patients: Clinical Presentation and New Methods of Treatment.- New Treatment Modalities for Basal Cell Carcinoma.- 5 Lymphoma Pathogenesis.- From Inflammation to Neoplasia: New Concepts in the Pathogenesis of Cutaneous Lymphomas.- Clinical Presentations.- Cutaneous Lymphomas and Pseudolymphomas: Newly Described Entities.- Clinical Aspects and Pathology of Primary Cutaneous B-Cell Lymphomas.- Diagnosis.- Modern Diagnosis of Cutaneous Lymphoma.- Therapy.- Treatment of Cutaneous T Cell Lymphoma: 2001.- New Biologic Agents for the Treatment of Cutaneous T-Cell Lymphoma.- 6 Mesenchymal Tumors.- Etiology and Pathogenesis of Kaposi's Sarcoma.- Connective Tissue Tumors.- 7 Psychosocial Aspects.- How to Identify Patients in Need of Psychological Intervention.- Psychotherapeutic Interventions in Melanoma Patients.
Summary
Skin cancer is the most frequent malignancy in humans and its incidence is still increasing. This situation calls for major efforts to manage the disease. Preventive measures must include reduced UV exposure and an enhanced common awareness of skin lesions. Advanced surgical techniques allow safe removal with excellent cosmetic results. In many cases alternative treatment modalities such as radiotherapy, cryosurgery and photodynamic therapy are applicable. The development of optimal sun screens and UV-protective clothes, new tools for early diagnosis of malignant lesions including videomicroscopy, improved evaluation of biopsy material and new treatment schemes will contribute to better patient care. New developments in therapy including pegylated interferons, cytokine-inducing molecules, monoclonal antibodies and vaccination approaches using peptides, dendritic cells, viruses or nDNA give hope for well-tolerated and efficient treatments.
