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Informationen zum Autor Linda C. Giudice , MD, PhD, University of California, San Francisco, CA, USA Hans L. H. Evers , MD, PhD, University of Maastricht, Netherlands David Healy , MB BS, PhD, Monash University, Melbourne, Australia Klappentext Science merged with clinical practice towards relieving the symptoms of endometriosisEndometriosis is frequently intensely painful and can lead to infertility causing disruption of women's lives and relationships. It can be a devastating condition. Major progress has been made in recent years on understanding the causes of endometriosis and developing effective clinical therapies.Endometriosis: Science and Practice fuses the scientific and clinical approaches. It marries the characteristics of the disease, how it presents and possible causes with medical and surgical approaches to pain therapy, and wider aspects of the disease.Broad in outlook, focused in application, Endometriosis: Science and Practice covers:* Pathogenesis* Disease Characterization* Biological basis of Endometriosis* Diagnosis* Medical Therapies* Surgical Therapies* Infertility* Associated DisordersThe stellar cast of contributors, led by world-leading editors from the US, Europe and Asia-Pacific, have produced a contemporary tour-de-force that should be on the bookshelf of anyone who provides medical care for women. Zusammenfassung * The first major textbook that integrates scientific and clinic understanding towards better patient care * Outlines information of recent developments, offering insight to improve management of symptoms medically or surgically * Written by an internationally well-known editor team . Inhaltsverzeichnis List of Contributors, viii Preface, xiii List of Abbreviations, xv Part 1: History, Epidemiology, and Economics 1 History of Endometriosis: A 20th-Century Disease, 3 Ivo Brosens and Giuseppe Benagiano 2 Endometriosis: Epidemiology, and Etiological Factors, 19 Fabio Parazzini, Paolo Vercellini and Claudio Pelucchi 3 Economic Perspective on Diagnosis and Treatment of Endometriosis, 27 Steven Simoens and Thomas M. D'Hooghe Part 2: Pathogenesis 4 Pathogenesis: Development of the Female Genital Tract, 35 Jolande A. Land and Johannes L.H. Evers 5 Theories on the Pathogenesis of Endometriosis, 42 Annemiek W. Nap 6 Understanding the Pathogenesis of Endometriosis: Gene Mapping Studies, 54 Jodie N. Painter, Krina T. Zondervan and Grant W. Montgomery 7 Pathogenesis: Epigenetics, 65 Sun-Wei Guo Part 3: Disease Characterization 8 Endometriosis: Disease Classification and Behavior, 81 G. David Adamson 9 Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities, 92 Jacques Donnez, Olivier Donnez, Jean-Christophe Lousse and Jean Squifflet 10 Extra-abdominal Endometriosis, 108 Antonio Bobbio, Diane Damotte, Anne Gompel and Marco Alifano Part 4: Biological Basis and Pathophysiology of Endometriosis 11 Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis, 117 Petra A. B. Klemmt and Anna Starzinski-Powitz 12 Stem Cells in Endometriosis, 130 Caroline E. Gargett, Hirotaka Masuda and Gareth C. Weston 13 Role of Steroid Hormones: Estrogen and Endometriosis, 140 Elke Winterhager 14 Role of Steroid Hormones: Progesterone Signaling, 145 Shirin Khanjani, Marwa K. Al-Sabbagh, Luca Fusi and Jan J. Brosens 15 Early Origins of Endometriosis: Role of Endocrine Disrupting Chemicals, 153 Germaine M. Buck Louis 16 Signaling Pathways in Endometriosis (Eutopic/Ectopic), 164 J. Julie Kim and Xunqin Yin 17 MicroRNAs in Endome...
