Biomechatronic Design in Biotechnology - A Methodology for Development of Biotechnological Products

Zusatztext ?This book effectively presents the methodology and most of the necessary tools for a design process in biotechnology... I thus recommend this book to students who want to learn the fundamentals and basic applications of a product design process quickly. It is also a good read for professors! researchers and professionals from both engineering and biology... In conclusion! this book is a must-read for all modern bio-scientists and engineers working in the field of biotechnology.?? Biotechnology Journal! 2012! 7 Informationen zum Autor Professor Carl-Fredrik Mandenius is head of the Division of Biotechnology at Linkoping University in Sweden. His main research interests include biochemical and bio-production engineering, bioprocess monitoring and control, stem cell technology, and biosensor technology. He was a director for process R&D at Pharmacia AB and has coordinated several EU networks on hESC-derived models for drug testing. Professor Mats Björkman is head of the Division of Assembly Technology at Linkoping University in Sweden. His main research interests include design and operation of flexible manufacturing systems and equipment. He has also been involved in research that has developed from traditional mechanical industries to include areas such as electronic manufacturing and manufacturing of biotech equipment, as well as pharmaceutical products. Klappentext A cutting-edge guide on the fundamentals, theory, and applications of biomechatronic design principles Biomechatronic Design in Biotechnology presents a complete methodology of biomechatronics, an emerging variant of the mechatronics field that marries biology, electronics, and mechanics to create products where biological and biochemical, technical, human, management-and-goal, and information systems are combined and integrated in order to solve a mission that fulfills a human need. A biomechatronic product includes a biological, mechanical, and electronic part. Beginning with an overview of the fundamentals and theory behind biomechatronic technology, this book describes how general engineering design science theory can be applied when designing a technical system where biological species or components are integrated. Some research methods explored include schemes and matrices for analyzing the functionality of the designed products, ranking methods for screening and scoring the best design solutions, and structuring graphical tools for a thorough investigation of the subsystems and sub-functions of products. This insightful guide also: Discusses tools for creating shorter development times, thereby reducing the need for prototype testing and verification Presents case study-like examples of the technology used such as a surface plasmon resonance sensor and a robotic cell culturing system for human embryonic stem cells Provides an interdisciplinary and unifying approach of the many fields of engineering and biotechnology used in biomechatronic design By combining designs between traditional electronic and mechanical subsystems and biological systems, this book demonstrates how biotechnology and bioengineering design can utilize and benefit from commonly used design tools- and benefit humanity itself. Zusammenfassung a must-read for all modern bio-scientists and engineers working in the field of biotechnology. Inhaltsverzeichnis PREFACE xiii 1 Introduction 1 1.1 Scope of Design / 1 1.2 Definition of Biomechatronic Products / 3 1.3 Principles of Biomechatronics / 4 1.4 Brief History of the Development of Biomechatronic Products and Engineering / 7 1.5 Aim of This Book / 9 References / 10 PART I FUNDAMENTALS 13 2 Conceptual Design Theory 15 2.1 Systematic Design / 15 2.1.1 Design for Products / 15 2.1.2 Origin of the Design Task / 18 2.1.3 ...

List of contents

PREFACE xiii
 
1 Introduction 1
 
1.1 Scope of Design / 1
 
1.2 Definition of Biomechatronic Products / 3
 
1.3 Principles of Biomechatronics / 4
 
1.4 Brief History of the Development of Biomechatronic Products and Engineering / 7
 
1.5 Aim of This Book / 9
 
References / 10
 
PART I FUNDAMENTALS 13
 
2 Conceptual Design Theory 15
 
2.1 Systematic Design / 15
 
2.1.1 Design for Products / 15
 
2.1.2 Origin of the Design Task / 18
 
2.1.3 Development of Design Thinking / 18
 
2.1.4 Recent Methods / 20
 
2.2 Basics of Technical Systems / 21
 
2.2.1 Energy, Material, and Signals and Their Conversion / 22
 
2.2.2 Interrelationships of Functions / 22
 
2.2.3 Interrelationship of Constructions / 25
 
2.2.4 Interrelationship of Systems / 25
 
2.3 Psychology in the Systematic Approach / 25
 
2.4 A General Working Methodology / 26
 
2.4.1 Analysis for Resolving Technical Problems / 27
 
2.4.2 Abstraction of Interrelationships of Systems / 28
 
2.4.3 Synthesis of the Technical System / 28
 
2.5 Conceptual Design / 28
 
2.6 Abstraction inOrder to Identify Essential Problems / 29
 
2.7 Developing the Concepts / 31
 
2.7.1 Organizing the Development Process / 33
 
2.8 Concluding Remarks / 34
 
References / 35
 
3 Biotechnology and Mechatronic Design 37
 
3.1 Transduction of the Biological Science into Biotechnology / 37
 
3.2 Biological Sciences and Their Applications / 39
 
3.3 Biotechnology and Bioengineering / 42
 
3.4 Applying Mechatronic Theory to Biotechnology: Biomechatronics / 44
 
3.5 Conclusions / 47
 
References / 48
 
4 Methodology for Utilization of Mechatronic Design Tools 49
 
4.1 Idea of Applying the Mechatronic Design Tools / 49
 
4.2 Table of User Needs / 51
 
4.3 List of Target Specifications / 52
 
4.4 Concept Generation Chart / 52
 
4.4.1 Basic Concept Component Chart / 53
 
4.4.2 Permutation Chart / 54
 
4.5 Concept Screening Matrix / 55
 
4.6 Concept Scoring Matrix / 56
 
4.7 Hubka-Eder Mapping / 57
 
4.7.1 Overview Hubka-Eder Map / 57
 
4.7.2 Zoom-in Hubka-Eder Mapping / 59
 
4.8 Functions Interaction Matrix / 60
 
4.8.1 Functions Interaction Matrix for Systems and Subsystems / 60
 
4.8.2 Functions Interaction Matrix for Systems and Transformation Process / 61
 
4.8.3 Design Structure Matrix / 61
 
4.9 Anatomical Blueprint / 62
 
4.10 Conclusions / 63
 
References / 63
 
PART II APPLICATIONS 65
 
5 Blood Glucose Sensors 67
 
5.1 Background of Blood Glucose Analysis / 67
 
5.2 Specification of Needs for Blood Glucose Analysis / 70
 
5.3 Design of Blood Glucose Sensors / 71
 
5.3.1 Generation of Sensor Concepts / 71
 
5.4 Description of the Systems Involved in the Design Concepts for Glucose Blood Sensors / 76
 
5.4.1 Biological Systems / 77
 
5.4.2 Technical Systems / 77
 
5.4.3 Information Systems / 78
 
5.4.4 Management and Goal Systems / 78
 
5.4.5 Human Systems / 79
 
5.4.6 Active Environment / 79
 
5.4.7 Interactions Between the Systems and Functions of the Design / 79
 
5.4.8 Anatomical Blueprints from the Functions Interaction Matrix Analysis / 81
 
5.5 Conclusions / 82
 
References / 82
 
6 Surface Plasmon Resonance Biosensor Devices 85
 
6.1 Introduction / 85
 
6.2 Design Requirements on

Report

"Over the past few years the field of biotechnological products, with roots in the fields of both mechanics and electronics, has achieved rapid advances in systematic design principles and methodology. The Swedish authors Carl-Fredrik Mendenius and Mats Björkman?s book Biomechatronic Design in Biotechnology aims to link aspects of biotechnology with mechanical and electrical engineering.
 
The content of the book is structured into two parts. The first part containing four chapters outlines the fundamentals of biomechatronic design dealing with the theory of conceptual design, biotechnology, mech atronic design, and the methodology for the use of mechatronic design tools. This concise and well-structured introduction of the basic terms and concepts shows the reader how to develop a conclusive approach to identify interrelationships between these fields, as well as how to analyze and abstract them. This is then followed by the identification of the essential biomechatronic design problems together with the organization of the development process of biotechnological products. Furthermore the first part of the book also covers the structuring of different methods of mechatronic design tools such as Hubka-Eder mapping, the use of function interaction matrices, design structure matrices as well as the anatomical blueprint. Consequently the authors briefly describe how electronics, mechanics and biotechnology overlap and why it is necessary to synthesize all three fields into biomechatronics.
 
The second part, applications, composed of nine chapters provides hands-on examples for the development of biotechnological devices and methods. The first chapter, dedicated to blood glucose sensors, is a perfect basic example of the development process. The chapter starts with background information and a list of specifications such as analytical devices the reader should possess. The chapter goes on to outline various conceptual designs, different systems and environments involved, and the required user specifications. This chapter is followed by the highly interesting topic of the construction of a surface plasmon resonance (SPR) biosensor device. Every part of this detection system is analyzed from a design perspective during the development pro cess of the system, meanwhile potential strategies for improvement are proposed. While the SPR technologies are well described and thoroughly analyzed, the processes described only take the BiacoreTM system from GE Healthcare and the SPREETATM system from Texas Instruments into account. The book would have benefitted from a comparison with other systems.
 
The next chapter in the second part addresses the very specific topic of the development process of a diagnostic device for Helicobacter pylori infection, a gastrointestinal infection that can cause gastritis with abdominal pain (stomach ache) or nausea. Several available testing methods are described in this chapter and their advantages are also compared. This chapter is followed by a mechatronic analysis of the urea breath test system in order to generate a collection of design alternatives. Once again, the various systems required are described and aspects of the design for efficient manufacturing are discussed. Similarly structured to other chapters, Chapter 8 discusses the design of microarray devices and concentrates on the needs and target specifications for DNA microarrays. Consequently the tools presented in the fundamentals sections are applied towards this conceptual design problem.
 
In chapter 9, on microbial and cellular bioreactors, a more intensive and detailed example is given that includes not only a distinctive system analysis but also a study of the interactions of the systems ordered by the different types of bioreactors and their application ranges from stem cell bioreactors to novel bioreactor systems. This must-read chapter contains lots of interesting insights and clever conclusions. For those interested in the topic, the research article by the same authors may also be relevant.
 
The next chapter is dedicated to chromatographic protein purification. In this chapter three different processes are explained: batch, membrane and chromatography configurations. The whole design process of stem cell manufacturing is outlined in chapter 11, which focuses on scale-up problems and the setup of a biomechatronic conceptual design. Bio-artificial organ-simulating devices is the topic of chapter 12 and mimics a living human or animal organ by recreating its essential functions. These devices can be used for the testing of new pharmaceuticals in vitro. In contrast to bioreactor systems described in earlier chapters, this is a far more advanced technology and its needs and specifications are more diverse. The authors conclude that for such a specific device the formulation of a clear mission is most important during the design process and outline the strategy. While this chapter is fairly short it is well written and points out the direction of research in terms of drug testing method development.
 
The book finishes with a chapter on process analytical technology (PAT) and quality-by-design (QbD) approaches. In this very interesting section of the book, the authors describe the different perspectives for an appropriate PAT process such as inter- scientific understanding and knowledge management. QbD and PAT approaches are synthesized into the conceptual design methodology (e.g. Hubka-Eder mapping).
 
This book effectively presents the methodology and most of the necessary tools for a design process in biotechnology. I thus recommend this book to students who want to learn the fundamentals and basic applications of a product design process quickly. It is also a good read for professors, researchers and professionals from both engineering and biology in order to get helpful input for their own device or method developments. In conclusion, this book is a must-read for all modern bio-scientists and engineers working in the field of biotechnology. "
 
- Biotechnology Journal, 2012, 7

Product details

• Authors: Bj?rkman, Mats Bjoerkman, Mats Mandenius Bjorkman, Mats Björkman, BJORKMAN MATS MANDENIUS CARL FRE, Mandenius, Carl-Fredri Mandenius, Carl-Fredrik Mandenius, Carl-Fredrik Bjoerkman Mandenius, Carl-Fredrik Bjorkman Mandenius, Carl-fredrik/ Bjorkman Mandenius, Cf Mandenius, Mandenius Carl-Fredrik
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 01.08.2011
• EAN: 9780470573341
• ISBN: 978-0-470-57334-1
• No. of pages: 304
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Miscellaneous; Biotechnologie, Life Sciences, Biowissenschaften, Biomedizinische Technik, biotechnology, Chemical Engineering, chemische Verfahrenstechnik, Biomedical engineering, Allg. Chemische Verfahrenstechnik, Biotechnologie i. d. Biowissenschaften, Biomedizintechnik, Allg. Biomedizintechnik, Biomechatronik