Psychiatric Disorders - Methods and Protocols

New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art "Omics approaches" and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful Methods in Molecular Biology(TM) series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.

List of contents

New Frontiers in Animal Research of Psychiatric Illness.- Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview.- Qualitative Vs. Quantitative Methods in Psychiatric Research.- Animal Models of Self-Injurious Behavior: An Overview.- Rodent Models of Adaptive Decision Making.- Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis.- Modeling Depression in Animal Models.- Behavioral Model for Assessing Cognitive Decline.- The Pemoline Model of Self-Injurious Behavior.- Modeling Risky Decision Making in Rodents.- Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes.- An Animal Model to Study the Molecular Basis of Tardive Dyskinesia.- Models of Chronic Alcohol Exposure and Dependence.- Rat Models of Prenatal and Adolescent Cannabis Exposure.- Modeling Nicotine Addiction in Rats.- Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal.- Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms.- Cocaine Self-Administration in Rats: Hold Down Procedures.- Cocaine Self-Administration in Rats: Discrete Trials Procedures.- Cocaine Self-Administration in Rats: Threshold Procedures.- Assessing Locomotor-Stimulating Effects of Cocaine in Rodents.- Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure.- Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight.- Animal Models of Overeating.- The Activity-Based Anorexia Mouse Model.- Dissociating Behavioral, Autonomic,and Neuroendocrine Effects of Androgen Steroids in Animal Models.- Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders.- Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines.- P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD).- Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure.- Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders.- ADHD Animal Model Characterization: Transcriptomics and Proteomics Analyses.- Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics.- Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research.- Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia.- Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations.- Data Mining in Psychiatric Research.

Summary

New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art “Omics approaches” and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models.  As a part of the highly successful Methods in Molecular Biology™ series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
 
Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.

Additional text

From the reviews:
“This is a comprehensive compilation of in vivo and in vitro neuropsychiatric research methods and protocols on animal models and cutting-edge techniques in the wide spectrum of psychiatric illnesses. … It is written for graduates, postdoctoral workers, and established scientists working on behavioral and molecular neuropsychiatric research. … The detailed methods and protocols make this a quality book for any researcher in the field of neuroscience and psychiatry.” (Valerie E. Mathis-Allen, Doody’s Book Reviews, May, 2012)

Report

From the reviews:
"This is a comprehensive compilation of in vivo and in vitro neuropsychiatric research methods and protocols on animal models and cutting-edge techniques in the wide spectrum of psychiatric illnesses. ... It is written for graduates, postdoctoral workers, and established scientists working on behavioral and molecular neuropsychiatric research. ... The detailed methods and protocols make this a quality book for any researcher in the field of neuroscience and psychiatry." (Valerie E. Mathis-Allen, Doody's Book Reviews, May, 2012)

Product details

• Assisted by: Fira H Kobeissy (Editor), Firas H Kobeissy (Editor), Firas H. Kobeissy (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 26.07.2011
• EAN: 9781617794575
• ISBN: 978-1-61779-457-5
• No. of pages: 615
• Weight: 1356 g
• Illustrations: XXI, 615 p.
• Series: Methods in Molecular Biology; Methods in Molecular Biology
• Subject: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine