Workbook for Organic Synthesis - Strategy and Control

Klappentext Workbook for Organic Synthesis: Strategy and ControlPaul WyattSenior Lecturer and Director of Undergraduate Studies! School of Chemistry! University of Bristol! UKStuart WarrenReader in Organic Chemistry! Department of Chemistry! University of Cambridge! UK.Workbook for Organic Synthesis: Strategy and ControlThis workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: Strategy and Control. Each problem is followed by a fully explained solution and discussion. The examples extend the student's experience of the types of molecules being synthesised by organic chemists! and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges! and build a toolkit of strategies for planning new syntheses. Together the workbook and textbook provide a complete course in advanced organic synthesis.Organic Synthesis: Strategy and ControlOrganic Synthesis: Strategy and Control is a sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach. The 'Disconnection' book concentrated on the planning behind the synthesis of compounds. This book focuses on putting the planning into practice.The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.The book is divided into five sections that deal with selectivity! carbon-carbon single bonds! carbon-carbon double bonds! stereochemistry and functional group strategy. Interpenetrating this structure! the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate entity.Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis. Zusammenfassung This workbook accompanies Organic Synthesis: Strategy and Control , the bestselling advanced organic chemistry textbook. The workbook provides a complete course for advanced organic chemistry students and includes a graded set of problems, solutions, and discussions to illustrate and develop the themes of each of the chapters in the textbook. Inhaltsverzeichnis Section A: Introduction: Selectivity1. Planning Organic Syntheses: Tactics! Strategy and Control2. Chemoselectivity3. Regioselectivity: Controlled Aldol Reactions4. Stereoselectivity: Stereoselective Aldol Reactions5. Alternative Strategies for Enone Synthesis6. Choosing a Strategy: The Synthesis of CyclopentenonesSection B: Making Carbon-Carbon Bonds7. The Ortho Strategy for Aromatic Compounds8. s-Complexes of Metals9. Controlling the Michael Reaction10. Specific Enol Equivalents11. Extended Enolates12. Allyl Anions13. Homoenolates14. Acyl Anion EquivalentsSection C: Carbon-Carbon Double Bonds15. Synthesis of Double Bonds of Defined Stereochemistry16. Vinyl Anions17. Electrophilic Attack on Alkenes18. Vinyl Cations19. Allyl Alcohols: Allyl Cation Equivalents (and More)Section D: Stereochemistry20. Control of Stereochemistry -- Introduction21. Diastereoselectivity22. Resolution23. The Chiral Pool: Asymmetric Synthesis with Natural Products as Starting Materials24. Asymmetric Induction I: Reagent-Based Strategy25. Asymmetric Induction II: Asymmetric Catalysis: Formation of C-O and C-N Bonds26. Asymmetric Induction III: Asymmetric Catalysis: Formation of C-H and C-C Bonds27. Asymmetric Induction IV: Substrate-Based Strategy28. Kinetic Resolution29. Enzymes: Biological Methods in Asymmetric Synthesis30. New Chiral Centres from Old: Ena...

List of contents

Section A: Introduction: Selectivity
 
1. Planning Organic Syntheses: Tactics, Strategy and Control
 
2. Chemoselectivity
 
3. Regioselectivity: Controlled Aldol Reactions
 
4. Stereoselectivity: Stereoselective Aldol Reactions
 
5. Alternative Strategies for Enone Synthesis
 
6. Choosing a Strategy: The Synthesis of Cyclopentenones
 
Section B: Making Carbon-Carbon Bonds
 
7. The Ortho Strategy for Aromatic Compounds
 
8. s-Complexes of Metals
 
9. Controlling the Michael Reaction
 
10. Specific Enol Equivalents
 
11. Extended Enolates
 
12. Allyl Anions
 
13. Homoenolates
 
14. Acyl Anion Equivalents
 
Section C: Carbon-Carbon Double Bonds
 
15. Synthesis of Double Bonds of Defined Stereochemistry
 
16. Vinyl Anions
 
17. Electrophilic Attack on Alkenes
 
18. Vinyl Cations
 
19. Allyl Alcohols: Allyl Cation Equivalents (and More)
 
Section D: Stereochemistry
 
20. Control of Stereochemistry -- Introduction
 
21. Diastereoselectivity
 
22. Resolution
 
23. The Chiral Pool: Asymmetric Synthesis with Natural Products as Starting Materials
 
24. Asymmetric Induction I: Reagent-Based Strategy
 
25. Asymmetric Induction II: Asymmetric Catalysis: Formation of C-O and C-N Bonds
 
26. Asymmetric Induction III: Asymmetric Catalysis: Formation of C-H and C-C Bonds
 
27. Asymmetric Induction IV: Substrate-Based Strategy
 
28. Kinetic Resolution
 
29. Enzymes: Biological Methods in Asymmetric Synthesis
 
30. New Chiral Centres from Old: Enantiomerically Pure Compounds & Sophisticated Syntheses
 
31. Strategy of Asymmetric Synthesis
 
Section E: Functional Group Strategy
 
32. Functionalisation of Pyridine
 
33. Oxidation of Aromatic Rings and of Enol(ate)s
 
34. Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements
 
35. Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms
 
36. Tandem Organic Reactions

Report

?This is a must-read for any final year undergrad or PhD? student in organic chemistry, but it s more than that?it s a book for experienced chemists too.? ( Reviews , May 2009)

Product details

• Authors: Paul Wyatt, Stuar Warren, Stuart Warren, Stuart (Cambridge University Warren, Stuart Wyatt Warren, WARREN STUART WYATT PAUL, P Wyatt, Paul Wyatt, Paul (School of Chemistry Wyatt, Paul Warren Wyatt
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 21.04.2008
• EAN: 9780470758830
• ISBN: 978-0-470-75883-0
• No. of pages: 500
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Chemie, Organische Chemie, ORGANIC CHEMISTRY, CHEMISCHE SYNTHESE, chemistry, Methods - Synthesis & Techniques, Organische Chemie / Methoden, Synthesen, Verfahren