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Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system.Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest.
List of contents
Contributors.- Preface. Hypertensive Heart Disease: Time for New Paradigms. Cardiac (PRO) Renin Receptors: Functional Properties and Potential Significance.- On the Relationship Between the Renin Receptor and the Vacuolar Proton-ATPase Membrane Sector-Associated Protein (M8-9).- Role of the AT2Receptor in Cardiovascular Function: A Brief Synopsis.- Reciprocal Regulation of Renin in JGA and Tubules in Hypertension.- Salt Loading a Paradigm for a Local Cardiac Renin-Angiotensin-Aldosterone System.- Lessons from Experimental Generation of Intracellular Angiotensinogen and AII.- On the Cardiac Renin Angiotensin System: The Heart as a Source of Angiotensin II.- The Hematopoietic System: A New Niche for the Renin-Angiotensin System.- Mechanical Signaling and the Cardiac Renin-Angiotensin.- Angiotensin Converting Enzyme 2: A Critical Regulator of the Renin-Angiotensin System.- Dyslipidemia and Angiotensin II and Atherogenesis.- ACE Inhibitors Directly Activate Bradykinin B1Receptors to Release NO.- Remodeling in Hypertensive Heart Disease: Role of the Renin-Angiotensin-Aldosterone System.- Cardiac Aldosterone Production: A Vascular Problem? Cellular Oxidative Stress, Aging and the Local RAS.- Index.
