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Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepatocytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into hepatocytes and biliary cells. This book is a collection of work on stem cell and liver regeneration, initially delivered at the 14th Yamaguchi (Japan) Symposium on Liver Disease. Its nine chapters present the most recent data about basic and clinical research in hepatology in Japan and other countries, providing a valuable resource for researchers and practitioners alike.
List of contents
1. SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF- k B-Induced Anti-Apoptosis.- 2. Promising Resources of Hepatic Progenitor Cells.- 3. Oncostatin M Promotes Differentiation of Fetal Hepatocytes in vitro and Regulates Liver Regeneration in vivo.- 4. Hepatocyte Growth Factor Accelerates Proliferation of Hepatic Oval Cells in a 2-Acetylarnmofluorene/Partial Hepatectomy Model in the Rat.- 5. Stem Cells and Liver Repopulation: Current Reality and Prospects for the Future.- 6. Strategy for the Development of Cell Therapy Using Bone Marrow Cells to Repair Damaged Liver.- 7. BcL-xL as a Critical Apoptosis Antagonist in Hepatocytes and Hepatocellular Carcinoma.- 8. Dedifferentiation and Proliferation of Hepatocellular Carcinoma: From Early to Advanced.- 9. Genome-Wide Analysis of Gene Expression in Hepatocellular Carcinoma.
Summary
Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepatocytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into hepatocytes and biliary cells. This book is a collection of work on stem cell and liver regeneration, initially delivered at the 14th Yamaguchi (Japan) Symposium on Liver Disease. Its nine chapters present the most recent data about basic and clinical research in hepatology in Japan and other countries, providing a valuable resource for researchers and practitioners alike.
