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Prion diseases recently have attracted interest not only scientifically but also socially because of the bovine spongiform encephalopathy (BSE) epidemic and the outbreak of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom. In 2004, the International Symposium of Prion Diseases for Food and Drug Safety was held October 31-November 2 in Sendai, Japan, where, 20 years earlier, arguments were first heard on whether the etiologic agent of transmissible spongiform encephalopathy was prions or scrapie-associated fibrils. This volume is a collection of current work on prion research that was presented at the 2004 symposium. Topics included range from basic research to clinical aspects of prion diseases, making the book a valuable resource for researchers and clinicians, and encouraging further developments by the next generation of researchers.
List of contents
Pathology of Variant Creutzfeldt-Jakob Disease.- Clinical aspects of Variant CJD.- Dura mater related Creutzfeldt-Jakob disease in Japan: Relationship between sites of grafts and clinical features.- Treatment options in patients with Prion Disease - the role of long term Cerebroventricular infusion of Pentosan Polysulphate.- Human prion diseases: novel diagnostic principles.- History and state of the art of PrP-res 'typing' in Creutzfeldt-Jakob disease.- Chronic wasting disease in Cervids in North America.- Bovine spongiform encephalopathy (BSE) in Japan.- The role of host PrP in control of incubation time.- The role of the immune system in TSE agent neuroinvasion.- Prion protein interactions and TSE infections in cell culture models.- Semi-classical quantization of protein dynamics: Novel NMR relaxation formalism and its application to Prion.
Summary
Prion diseases recently have attracted interest not only scientifically but also socially because of the bovine spongiform encephalopathy (BSE) epidemic and the outbreak of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom. In 2004, the International Symposium of Prion Diseases for Food and Drug Safety was held October 31–November 2 in Sendai, Japan, where, 20 years earlier, arguments were first heard on whether the etiologic agent of transmissible spongiform encephalopathy was prions or scrapie-associated fibrils. This volume is a collection of current work on prion research that was presented at the 2004 symposium. Topics included range from basic research to clinical aspects of prion diseases, making the book a valuable resource for researchers and clinicians, and encouraging further developments by the next generation of researchers.
