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Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes.
In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
List of contents
CHEMISTRY OF NO DONORSNOand NO DonorsOrganic Nitrates and NitritesN-Nitroso CompoundsThe Role of S-Nitrosothiols in the Biological MilieuMetal-NO ComplexesNO Releasing HeterocyclesC-nitroso compounds, Oximes, N-hydroxyguanidines and N-hydroxyureasNO DONORS' APPLICATIONS IN BIOLOGICAL RESEARCHVasodilators for Biological ResearchNO Donors as Antiplatelet AgentsControl of NO ProductionCLINICAL APPLICATIONS OF NO DONORSNO Donors in Cardiovascular DiseaseNO Donors as Anti-Platelet Agents for thromboembolic disordersNO and Gene RegulationNO and Central Nervous System Diseases
About the author
Naoyuki Taniguchi graduated from the Hokkaido University School of Medicine, followed by an M.D. degree in 1967, and completed the doctoral course of medicine at the Graduate School of Hokkaido University and obtained a Ph.D in 1972. He was then appointed assistant professor at the Hokkaido University School of Medicine in 1975 and was a visiting professor in the group of Dr. Alton Meister at Cornell University Medical College between 1976 and 1977. Returning to Hokkaido University, he joined the Biochemistry Laboratory at the Cancer Institute, before being appointed as a full professor at the Department of Biochemistry, Osaka University Medical School in 1986. Professor Taniguchi is an honorary member of the American Society for Biochemistry and Molecular Biology and has received numerous awards, among them the International Glycoconjugate Organization (IGO) Award in 2001.
Peng George Wang obtained his B.S. degree in Chemistry from Nankai University, China in 1984 and his Ph.D. degree in organic chemistry from the University of California, Berkeley in 1990. He then conducted postdoctoral research at the Scripps Research Institute and in 1994 became an Assistant Professor at the University of Miami. From 1997 to 2003, he was a faculty member of Wayne State University. In 2003, he took his current position in the Departments of Biochemistry and Chemistry as Ohio Eminent Scholar in Macromolecular Structure and Function at the Ohio State University.
In 2002, Professor Wang has won the Isbell Award from the Divison of Carbohydrate Chemistry of the American Chemical Society.
