Destruction of Hazardous Chemicals in the Laboratory 3e

Informationen zum Autor George Lunn, PhD, has been working as a review chemist for the FDA's Office of New Drug Quality Assessment since 1996. Previously, he was a senior research scientist in the Environmental Control and Research Program at the NCI-Frederick Cancer Research and Development Center. He has written nine books and over sixty papers and review articles.Eric B. Sansone, PhD, was the director of the Environmental Control and Research Program at the NCI-Frederick Cancer Research and Development Center until his retirement. He has also worked as a consultant in industrial hygiene and air pollution control for a widely diversified group of industries, law firms, universities, and governmental agencies. He has published many articles on the assessment of risk in cancer research. Klappentext The book describes practical procedures for the destruction of hazardous chemicals and biological agents in the laboratory in which they are used. The book is a continuation and expansion of "Destruction of Hazardous Chemicals in the Laboratory." It follows the same general approach as the first and second editions but includes a number of new chapters including one on using advanced oxidation techniques as a general means of degrading chemicals. All the monographs from the second edition are incorporated in this volume and are revised and extended as necessary. A number of new monographs describing procedures for the destruction of hazardous chemicals have also been added.The destruction of many pharmaceuticals is also described in this book. This subject has become of increasing importance with recent reports of the detection of pharmaceuticals in the water supply. Finally a new addition is the chapter "General Methods for the Destruction of Hazardous Chemicals in the Laboratory." This chapter describes recent advanced oxidation methods that should be generally applicable to all organic compounds. The methods use commonly available laboratory equipment and reagents. Zusammenfassung The book describes practical procedures for the destruction of hazardous chemicals and biological agents in the laboratory in which they are used. The book is a continuation and expansion of "Destruction of Hazardous Chemicals in the Laboratory." It follows the same general approach as the first and second editions but includes a number of new chapters including one on using advanced oxidation techniques as a general means of degrading chemicals. All the monographs from the second edition are incorporated in this volume and are revised and extended as necessary. A number of new monographs describing procedures for the destruction of hazardous chemicals have also been added.The destruction of many pharmaceuticals is also described in this book. This subject has become of increasing importance with recent reports of the detection of pharmaceuticals in the water supply. Finally a new addition is the chapter "General Methods for the Destruction of Hazardous Chemicals in the Laboratory." This chapter describes recent advanced oxidation methods that should be generally applicable to all organic compounds. The methods use commonly available laboratory equipment and reagents. Inhaltsverzeichnis PREFACE xiACKNOWLEDGMENTS xiiiINTRODUCTION 1SPECIFIC METHODS FOR THE DESTRUCTION OF HAZARDOUS CHEMICALS IN THE LABORATORY 17Acetonitrile 19Acid Halides and Anhydrides 23Aflatoxins 29Alkali and Alkaline Earth Metals 37Alkali Metal Alkoxides 41Anatoxin-A 43Aromatic Amines 47Arsenic 57Azides 61Azo and Azoxy Compounds and Tetrazenes 69Boron Trifluoride and Inorganic Fluorides 77Botulinum Toxins 81Brevetoxins 85Butyllithium 89Calcium Carbide 93Carbamic Acid Esters 95Carbofuran 99Chloromethylsilanes and Silicon Tetrachloride 101N-Chlorosuccinimide and Chloramine-T 103Chlorosulfonic Acid 105Chromium(VI) 107Citrinin 113Complex Metal Hydrides 121Cyanides and Cyanogen Bromide 129...

List of contents

PREFACE xiACKNOWLEDGMENTS xiiiINTRODUCTION 1SPECIFIC METHODS FOR THE DESTRUCTION OF HAZARDOUS CHEMICALS IN THE LABORATORY 17Acetonitrile 19Acid Halides and Anhydrides 23Aflatoxins 29Alkali and Alkaline Earth Metals 37Alkali Metal Alkoxides 41Anatoxin-A 43Aromatic Amines 47Arsenic 57Azides 61Azo and Azoxy Compounds and Tetrazenes 69Boron Trifluoride and Inorganic Fluorides 77Botulinum Toxins 81Brevetoxins 85Butyllithium 89Calcium Carbide 93Carbamic Acid Esters 95Carbofuran 99Chloromethylsilanes and Silicon Tetrachloride 101N-Chlorosuccinimide and Chloramine-T 103Chlorosulfonic Acid 105Chromium(VI) 107Citrinin 113Complex Metal Hydrides 121Cyanides and Cyanogen Bromide 129Cylindrospermopsin 137Diisopropyl Fluorophosphate 141Dimethyl Sulfate and Related Compounds 151Dyes and Biological Stains 163Ethidium Bromide 201Haloethers 211Halogenated Compounds 217Halogens 229Heavy Metals 233Hexamethylphosphoramide 241Hydrazines 245Hypochlorites 257Mercury 2612-Methylaziridine 2671-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 271Microcystins 2774-Nitrobiphenyl 2833-Nitrofluoranthene and 3-Aminofluoranthene 287Nitrogen Tetroxide 291N-Nitroso Compounds: Nitrosamides 293N-Nitroso Compounds: Nitrosamines 307Ochratoxin A 319Organic Nitriles 327Osmium Tetroxide 331Palytoxin 335Patulin 339Peracids 347Perchlorates 349Peroxides and Hydroperoxides 355Phenol 359Phosgene 363Phosphorus and Phosphorus Pentoxide 367Picric Acid 371Polycyclic Aromatic Hydrocarbons 375Polycyclic Heterocyclic Hydrocarbons 387Potassium Permanganate 405b-Propiolactone 407Protease Inhibitors 411Ricin 417Saxitoxin 421Selenium Compounds 425Sodium Amide 427Sterigmatocystin 429Sulfonyl Fluoride Enzyme Inhibitors 437Sulfur-Containing Compounds 443T-2 Toxin 449Tetrodotoxin 455Triacetone Triperoxide 459Uranyl Compounds 463METHODS FOR THE DESTRUCTION OF PHARMACEUTICALS IN THE LABORATORY 467Pharmaceuticals: General Considerations 469A: Potassium Permanganate 549B: Sodium Hypochlorite 567C: Nickel-Aluminum Alloy Reduction 575D: Fenton's Reagent 583E: Photo-Fenton Reaction 587F: Hydrogen Peroxide 591G: Hydrogen Peroxide and Horseradish Peroxidase 593H: Ozone 595I: Hydroxylamine Degradation of b-Lactams 603J: Miscellaneous Chemical Degradation Procedures 605K: Photolytic Degradation Procedures 613L: Decontamination of Aqueous Solutions 627NONSPECIFIC METHODS FOR THE DESTRUCTION OF HAZARDOUS CHEMICALS IN THE LABORATORY 631APPENDIXES 655APPENDIX I: Procedures for Drying Organic Solvents 657APPENDIX II: Safety Considerations with Potassium Permanganate 661MOLECULAR FORMULA INDEX 671CAS REGISTRY NUMBER INDEX 681CROSS INDEX OF PHARMACEUTICAL NAMES 693CROSS-INDEX OF NAMES FOR DYES AND BIOLOGICAL STAINS 729NAME INDEX 757

Report

"The book provides a good survey on destruction methods suitable for small and medium sized laboratories. The well-structured writing style provides an interesting textbook, helpful for every laboratory technician, and a reference book for supervisors responsible for the laboratory work." ( Materials and Corrosion , 1 August 2012)

"The writing is clear and precise, molecular structures and diagrams are clearly labelled, and procedures appear to be up-to-date, efficient, and adaptable . . . Summing Up: Essential. Graduate students through professionals/practitioners in academic, commercial, or industrial chemical laboratories." ( Choice , 1 November 2012)

Product details

• Authors: Richard C. Fink, G Lunn, Georg Lunn, George Lunn, George Sansone Lunn, LUNN GEORGE SANSONE ERIC B FINK, Eric B Sansone, Eric B. Sansone
• Assisted by: George Lunn (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 01.03.2012
• EAN: 9780470487556
• ISBN: 978-0-470-48755-6
• No. of pages: 800
• Subject: Natural sciences, medicine, IT, technology > Chemistry