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Informationen zum Autor Raymond P. Donnelly, Food and Drug Administration, Rockville, MD. Klappentext Cytokines are protein messengers responsible for cellular communication with great therapeutic potential to control inflammatory and immune disorders such us cancer, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Despite the solid scientific rationale for this therapeutic promise, many cytokine-related therapies have failed to establish clinical utility.In March 2009, international experts from academia, industry and government convened to discuss the scientific and clinical basis for the successes and failures of recombinant cytokines and cytokine antagonists as therapeutic agents, and possible strategies for improving their clinical success. This volume included extended versions of key presentations at the meeting.Participants examined:* Improved methods for identifying disease targets* Alternative methods for enhancing and targeting cytokine delivery* Physicochemical modification of cytokines to prolong their bioavailabilityNOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member. Zusammenfassung This volume highlights key presentations from a meeting of international experts from academia, industry and government convened to discuss the scientific and clinical basis for the successes and failures of recombinant cytokines and cytokine antagonists as therapeutic agents, and possible strategies for improving their clinical success. Inhaltsverzeichnis An overview of cytokines and cytokine antagonists as therapeutic agents 1 Pharmacologic administration of interleukin-2: inducing a systemic autophagic syndrome? 14 Perspective on potential clinical applications of recombinant human interleukin-7 28 Immune modulation with interleukin-21 39 Clinical and immunologic basis of interferon therapy in melanoma 47 Heterogeneous, longitudinally stable molecular signatures in response to interferon-beta 58 Clinical use of interferon-gamma 69 Interferon lambda as a potential new therapeutic for hepatitis C 80 Cytokines as targets for anti-inflammatory agents 88 Ustekinumab: lessons learned from targeting interleukin-12/23p40 in immune-mediated diseases 97 Blocking interleukin-1 in rheumatic diseases: its initial disappointments and recent successes in the treatment of autoinflammatory diseases 111 Rilonacept: CAPS and beyond, a scientific journey 124 Actobiotics as a novel method for cytokine delivery: the interleukin-10 case 135 Hurdles and leaps for protein therapeutics: cytokines and inflammation 146 ...
