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Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped - and who continue to shape - the field today.
List of contents
PART I: FOUNDATIONS
Studying the Molecules of Life
DNA: The Repository of Biological Information
Chemical Basis of Information Molecules
Protein Structure
Protein Function
PART II: NUCLEIC ACID STRUCTURE& METHODS
DNA and RNA Structure
Studying Genes
Genomes, Transcriptomes, and Proteomes
Topology: Functional Deformations of DNA
Nucleosomes, Chromatin, and Chromosome Structure
PART III: INFORMATION TRANSFER
DNA Replication
DNA Mutation and Repair Moment of Discovery
Homologous Recombination
Site-Specific Recombination and Transposition
DNA-Dependent Synthesis of RNA
RNA Processing
The Genetic Code
Protein Synthesis
PART IV: REGULATION
Regulating the Flow of Information
The Regulation of Gene Expression in Bacteria
Transcriptional Regulation of Gene Expression in Eukaryotes
Post-Transcriptional Regulation of Gene Expression in Eukaryotes
Gene Regulation in Development
Online Appendix: Model Organisms
About the author
Michael M. Cox lehrt Biochemie an der University of Wisconsin-Madison.
Michael O'Donnell received his Ph.D. at the University of Michigan, USA, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. O'Donnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University, USA in 1996. O'Donnell is a member of the National Academy of Sciences.
Jennifer A. Doudna grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley, USA, and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in Biochemistry from Pomona College, USA, and her Ph.D. from Harvard University, USA, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research. She next went to the University of Colorado, USA, as a Lucille P. Markey scholar and postdoctoral fellow with Thomas Cech. Doudna has also been a Donaghue Young Investigator, a Searle scholar, and a Beckman Young Investigator, and she is a former fellow of the David and Lucile Packard Foundation. She has received numerous awards for her research on RNA and RNA-protein structure and function.
