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Informationen zum Autor A Barry Kay, National Heart and Lung Institute, London, UK Allan P Kaplan, National Allergy and Asthma Centre, South Carolina, USA Jean Bousquet, Hopital Arnaud dde Villeneuve, Montpellier, France Patrick G Holt , Telethon Institute for Child Health, Perth, Australia Klappentext Allergy and Allergic Disease is an outstanding reference source on all aspects of allergy and allergic diseases. Covering every allergic condition, from the immunological and molecular basis of the allergic response to the future trends in allergic disease prevention, this new international editorial team lead by Professor Kay have completely revised and updated the text to take account of new and recent developments, from both a scientific and clinical perspective.The second edition will continue as two volumes, containing over 100 chapters and will deal with the immunologic basis of the allergic response and then with the cells and mediators responsible for allergic inflammation. Descriptions of the pharmacology and physiology of allergic diseases will be given, and then each specific allergic disease and their management are addressed.The new edition will contain 14 principal sections, and an increased coverage of drug allergens and allergic hypersensitivity reaction to drugs and the field of genetics will be revised accordingly.This second edition includes a fully searchable CD ROM including a database of 100 colour images. Zusammenfassung Reserve your copy now This two volume book is an outstanding reference source on all aspects of allergy and allergic diseases. Covering virtually every allergic condition, from the immunological and molecular basis of the allergic response to future trends in allergic disease prevention, this new international editorial team (A.B. Inhaltsverzeichnis List of Contributors ix Foreword xvii Preface xviii VOLUME 1 The Scientific Basis of Allergy Part 1 Immunology of the Allergic Response 1 Allergy and Hypersensitivity: History and Concepts 3 A. Barry Kay 2 Development of Allergy and Atopy 23 Catherine Thornton and Patrick G. Holt 3 T Cells and Cytokines in Asthma and Allergic Inflammation 48 Chris Corrigan 4 Regulatory T Cells and Other Tolerogenic Mechanisms in Allergy and Asthma 83 Catherine Hawrylowicz and Cezmi A. Akdis 5 IgE and IgE Receptors 103 Brian J. Sutton, Andrew J. Beavil, Rebecca L. Beavil, and James Hunt 6 Immunoglobulin Gene Organization and Expression and Regulation of IgE 119 Hannah J. Gould and David J. Fear 7 Environmental Factors in IgE Production 141 Anne Tsicopoulos, Catherine Duez, and Andrew Saxon 8 Antigen-presenting Dendritic Cells and Macrophages 166 Bart N. Lambrecht and Hamida Hammad 9 Innate Immunity in Allergic Disease 187 Ian Sabroe 10 Signal Transduction in Allergic and Inflammatory Cells 203 Rafeul Alam Part 2 Inflammatory Cells and Mediators 11 Mast Cells: Biological Properties and Role in Health and Allergic Diseases 217 Peter Bradding and Glenn Cruse 12 Eosinophils: Biological Properties and Role in Health and Disease 258 Simon P. Hogan, Helene F. Rosenberg, Redwan Moqbel, Simon Phipps, Paul S. Foster, Paige Lacy, A. Barry Kay, and Marc E. Rothenberg 13 Neutrophils: Biological Properties and Role in Health and Allergic Diseases 295 Alison M. Condliffe, Andrew S. Cowburn, and Edwin R. Chilvers 14 Basophils: Biological Properties and Role in Allergic Diseases 320 Gianni Marone, Giuseppe Spadaro, and Arturo Genovese 15 Leukocyte Adhesion in Allergic Inflammation 337 Michelle J. Muessel and Andrew J. Wardlaw 16 Airway Epithelium 366 <...
