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Recent advances in large-scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Two-dimensional gel electrophoresis can be used to create cellular protein maps which give a quantitative and qualitative picture of the proteome. Mass spectrometry is the method of choice for the rapid large-scale idenfification of these proteomes and their modifications. An understanding of these methods is critical for scientists in the "Post-Genome" era.
Über den Autor / die Autorin
Peter James, geb. 1948, ist Schriftsteller und Filmproduzent. Er hat lange Jahre in den USA gelebt und leitet mittlerweile in London seine eigene Filmproduktionsfirma. Seine beiden vorherigen Thriller mit Roy Grace Stirb Ewig und Stirb Schön sind in mehr als 27 Länder verkauft worden.§Peter James wurde für seinen ersten Roman als bester Krimischriftsteller mit dem Krimi-Blitz 2005 ausgezeichnet, außerdem erhielt er in Frankreich den begehrten Prix Polar International 2006 und den renommierten Prix Coeur Noir 2007.
Zusammenfassung
Recent advances in large-scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Two-dimensional gel electrophoresis can be used to create cellular protein maps which give a quantitative and qualitative picture of the proteome. Mass spectrometry is the method of choice for the rapid large-scale idenfification of these proteomes and their modifications. An understanding of these methods is critical for scientists in the "Post-Genome" era.
