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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
Zusammenfassung
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
Zusatztext
From the reviews:
“The volume is dedicated to the recent advances on PEGylation and PEGylated compunds. It represents an excellent update in the evolution of this field, from nanoscience to clinical applications. The book provides an excellent update in this rapidly evolving field. … This valuable volume which will spark the interest of both researchers and clinicians contributes to a better understanding of polymer therapeutics.” (Magdalena Moisei, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)
Bericht
From the reviews:
"The volume is dedicated to the recent advances on PEGylation and PEGylated compunds. It represents an excellent update in the evolution of this field, from nanoscience to clinical applications. The book provides an excellent update in this rapidly evolving field. ... This valuable volume which will spark the interest of both researchers and clinicians contributes to a better understanding of polymer therapeutics." (Magdalena Moisei, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)
