Drug Metabolism and Transport Molecular Methods and Mechanisms

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

Zusammenfassung

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

Zusatztext

"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society

Bericht

"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society

Produktdetails

• Mitarbeit: Lawrence H Lash (Herausgeber), Lawrence H. Lash (Herausgeber)
• Verlag: Springer, Berlin
• Inhalt: Buch
• Produktform: Fester Einband
• Erscheinungsdatum: 17.04.2009
• Thema: Naturwissenschaften, Medizin, Informatik, Technik > Medizin > Pharmazie
• EAN: 9781588293244
• ISBN: 978-1-58829-324-4
• Anzahl Seiten: 388
• Illustration: X, 388 p. 110 illus.
• Abmessung (Verpackung): 17 x 24.5 x 2.5 cm
• Gewicht (Verpackung): 779 g
• Serie: Methods in Pharmacology and Toxicology; Methods in Pharmacology and To; Methods in Pharmacology and To; Methods in Pharmacology and Toxicology
• Themen: B, Research, Resistance, METABOLISM, Pharmacy, Biomedical and Life Sciences, Drug Resistance, Toxicology, Toxicity, Xenobiotics, xenobiotic