Mehr lesen
Informationen zum Autor Helen MI Osborn, Dept of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD h.m.i.osborn@reading.ac.uk Tariq H Khan, Medicinal Chemistry Team Leader, Enzacta Ltd - Biotechnology company based in Porton Down, Salisbury. Carbohydrates are associated with a plethora of important biological processes and have been implicated in the onset and progress of many lethal diseases. They have attracted a great deal of recent research interest from both synthetic chemists and glycobiologists, and have been identified as novel targets of therapeutic importance. This book, aimed at synthetic and medicinal chemists, introduces both undergraduates and research students to the chemistry and biology of carbohydrates. The text investigates methods for synthesizing carbohydrates in a systematic and logical manner and provides real examples from the literature to exemplify the procedures introduced. Both traditional and modern methods for synthesizing carbohydrates, including enzymatic and solid- phase techniques, are discussed. Zusammenfassung Many universities are introducing courses in Carbohydrate Chemistry and Medicinal Chemistry within their undergraduate and graduate courses. This is a result of recent research within carbohydrate science that has highlighted the importance of these previously poorly understood biomolecules. Few books are currently available which cover carbohydrate synthesis and biology within one text. CHAPTER 1: INTRODUCTION; Location of oligosaccharides; Therapeutic potential; Nomenclature; Structural representation; Problems associated with oligosaccharide assembly; Further reading; CHAPTER 2: BIOLOGICAL ROLES OF OLIGOSACCHARIDES; Biosynthesis of some biologically important oligosaccharides; Carbohydrates as carriers of biological information; Lectins: Carbohydrate binding proteins; Diseases in which oligosaccharides play an important role; Further reading; CHAPTER 3: SYNTHESIS OF CARBOHYDRATE ACCEPTORS; General introduction to protecting group strategies; Specific protecting group strategies; Selection protection reactions; Synthesis of branched chain oligosaccharides; Further reading; CHAPTER 4: SYNTHESIS OF CARBOHYDRATE DONORS; Glycosyl acetates and thioglycosides; Glycosyl halides; Glycosyl selenides; Trichloroacetimidates; n-Pentyl glycosides; Vinyl glycosides; Glycals; Further reading; CHAPTER 5: ASSEMBLY OF OLIGOSACCHARIDES; Methods to control the configuration of newly formed anomeric bonds; Synthesis of beta-linked mannopyranosides; One pot synthesis of oligosaccharides; Further reading; CHAPTER 6: LITERATURE EXAMPLES OF OLIGOSACCHARIDES; An efficient synthesis of a high mannose type nonasaccharide; Stereoselective construction of the tetrasaccharyl cap portion of Leishmania lipophosphoglycan; A highly convergent synthesis of the tetragalactose moiety of the glycosyl phosphatidyl inositol anchor of the variant surface glycoprotein of Trypanosoma brucei; Synthesis of sialyl-Lewis; Further reading; CHAPTER 7: ALTERNATIVE STRATEGIES FOR SYNTHESISING OLIGOSACCHARIDES; Enzymatic synthesis of oligosaccharides; Polymer supported synthesis of oligosaccharides; Specific examples of polymer supported synthesis; Polymer supported synthesis employing enzymes; Further reading...
