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Informationen zum Autor Claudiu T. Supuran is a professor in the Department of Chemistry at the University of Florence, Italy. His main research interests include medicinal chemistry, design of enzyme inhibitors and activators, X-ray crystallography of metallo-enzymes, and metal complexes with biologically active ligands (metal-based drugs). He has published more than 400 original research papers in these fields. Jean-Yves Winum is an assistant professor in the Department of Chemistry at the University of Montpellier 2 (Institut des Biomolécules Max Mousseron UMR CNRS 5247), France. His research interests are focused on organic/medicinal chemistry of metallo-enzyme inhibitors and activators. Klappentext Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymesThe second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context.With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as:* Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G* Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions* Cross reactivity of zinc-enzyme inhibitors and activators* The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins* Clinical applicationsAn essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators. Zusammenfassung The book gives students and young researchers a resource on zinc enzymes, some of which were intensively studied for more than six decades and translated into model success stories of the pharmaceutical industry. Inhaltsverzeichnis PREFACE. CONTRIBUTORS. PART I: INTRODUCTION. 1. Introduction to Zinc Enzymes as Drug Targets ( Claudiu T. Supuran and Jean-Yves Winum ). PART II: DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS. 2. Carbonic Anhydrases as Drug Targets: General Presentation ( Claudiu T. Supuran ). 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors ( Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, and Claudiu T. Supuran ). 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design ( Vincenzo Alterio, Anna Di Fiore, Katia D'Ambrosio, Claudiu T. Supuran, and Giuseppina De Simone ). 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs ( Francesco Mincione, Andrea Scozzafava, and Claudiu T. Supuran ). 6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs ( Daniela Vullo, Alessio Innocenti, and Claudiu T. Supuran ). 7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents ( Anne Thiry, Jean-Michel Dogn e, Claudiu T. Supuran, and Bernard Masereel ). 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII ( Silvia Pastorekova, Monika Barathova, Juraj Kopacek, and Jaromir Pastorek ). 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for...