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For bacteria ..."the times are achanging"... The genomes of over 60 different bacteria have now been sequenced, and we know a lot about the important research organism Escherichia coli, the important industrial organism Bacillus subtilis, and about important plant and human pathogens. It will not take long before we know all the gene products and their functions of a few of these bacteria. Some of us already begin to think about a digital model E. coli or Bacillus cell. For that end we need to know all the physiological activities and metabolic routes of the cell. But in addition we like to know how things work at the molecular level and how protein and membranes as well as other (macromolecular) structures work together to carry out specific cell functions.
Protein Secretion Pathways in Bacteria describes all the known folding and targeting routes of inner and outer membrane proteins as well as of proteins that are secreted by several specific export routes. The book gives detailed molecular information about the structures that are important for the different mechanisms involved. This is a valuable contribution to the understanding of how rather simple and yet complex bacterial cells work.
List of contents
1. Protein Targeting to the Inner Membrane.- 2. The SEC Translocase.- 3. The TAT Protein Export Pathway.- 4. Assembly of Inner Membrane Proteins in Escherichia coli.- 5. Biogenesis of Outer Membrane Proteins.- 6. Chaperones and Folding Catalysts Involved in the General Protein Secretion Pathway of Escherichia coli.- 7. Type I Protein Secretion Systems in Gram-Negative Bacteria: Escherichia coli ?-Hemolysin Secretion.- 8. Type II Protein Secretion.- 9. The Type III Secretion Pathway in Pathogenic Bacteria.- 10. Autotransporters.- 11. Assembly of Adhesive Organelles on Gram-Negative Bacteria.- 12. Export of Bacteriocins.- 13. Biogenesis of Flagella: Export of Flagellar Proteins via the Flagellar Machine.- 14. Protein Secretion in Gram-Positive Bacteria.
