Advances in Novel Formulations for Drug Delivery

ADVANCES in NOVEL FORMULATIONS for DRUG DELIVERY
 
The 27 chapters describe novel strategies for drug/nutraceutical delivery and embrace the development of formulations with herbal ingredients, while also highlighting disease therapeutics.
 
Drug delivery technology has witnessed many advancements purported to cater to the customized needs of its ultimate beneficiaries--the patients. Today, dosage forms are not confined to conventional tablets, capsules, or injectables, but have evolved to cover novel drug carriers such as particulates, vesicles, and many others. Nanotechnological advancements have played a major role in this paradigm shift in ways of delivering active pharmaceutical ingredients.
 
A new dimension in the use of food as medicine has also gained prominence in recent years. A portmanteau of nutrition and pharmaceuticals is "nutraceuticals," also known as functional foods and dietary supplements. The technologies which were earlier included in drug delivery have been attempted for the delivery of nutraceuticals as well. Herbal actives have received increased attention due to their low risk-to-benefit ratio. The field of drug delivery is quite dynamic in nature, as witnessed by its evolution from conventional dosage forms to nanotechnology-assisted drug products. A variety of formulations via different drug delivery routes have been developed to treat/cure/mitigate diseases or disorders.
 
This book, comprising of 27 chapters, is a thorough compilation of information relevant to drug delivery systems with an emphasis on products based on nanotechnology.
 
Audience
 
Researchers, scientists, industry professionals, formulators and product developers, regulatory agencies in a variety of settings including novel drug delivery research laboratories, pharmaceutical, and pharmacy industries, biomedical sciences, food and nutraceuticals manufacturers, and nanotechnology.

List of contents

Preface xxiii
 
Part I: Novel Drug Carriers and Therapeutics 1
 
1 Nanoarchitectured Materials: Their Applications and Present Scenarios in Drug Delivery 3
Moreshwar P. Patil and Lalita S. Nemade
 
1.1 Introduction 3
 
1.2 Liposomes 4
 
1.3 Nanoparticles 8
 
1.3.1 Nanoparticles in Drug Delivery 9
 
1.4 Nanoemulsions 10
 
1.4.1 Advantages and Shortcomings of Nanoemulsions 10
 
1.4.2 Application of Nanoemulsion in Drug Delivery 10
 
1.5 Dendrimers 11
 
1.5.1 Synthesis of Dendrimers 12
 
1.5.2 Advantages of Dendrimers 12
 
1.5.3 Applications of Dendrimers in Drug Delivery 12
 
1.6 Aquasomes 15
 
1.6.1 Properties of Aquasomes 15
 
1.6.2 Application of Aquasomes in Drug Delivery 16
 
1.7 Nanogel 16
 
1.7.1 Properties of Nanogels 17
 
1.7.2 Nanogels in Drug Delivery 17
 
1.8 Quantum Dots 18
 
1.8.1 Applications of Quantum Dots in Drug Delivery 19
 
1.9 Carbon Nanotubes 19
 
1.9.1 Features of Carbon Nanotubes 19
 
1.9.2 Carbon Nanotubes in Drug Delivery 20
 
References 20
 
2 Nanopharmaceuticals for Drug Delivery 29
Swapnali Ashish Patil, Akshadha Atul Bakliwal, Vijay Sharad Chudiwal and Swati Gokul Talele
 
2.1 Introduction 29
 
2.2 What Are Nanopharmaceuticals and What Do They Do? 30
 
2.3 Nanopharmaceuticals Importance 30
 
2.4 Nanotechnology 30
 
2.5 Pharmaceutical Companies and Nanotechnology 31
 
2.6 Applications and Advantages of Nanopharmaceuticals as Drug Carriers 32
 
2.7 Characteristics of Nanoparticles in Nanopharmaceuticals 32
 
2.7.1 Particle Size 32
 
2.7.2 Surface Properties of Nanoparticles 33
 
2.7.3 Drug Loading 33
 
2.7.4 Drug Release 34
 
2.8 Targeted Drug Delivery 34
 
2.9 Types of Nanoparticles 34
 
2.10 Nanoparticle Preparation Methods 35
 
2.11 Evaluation of Nanoparticles 35
 
2.12 Efficiency of Drug Entrapment 37
 
2.13 Particle Shape 37
 
2.14 Size of the Particles 37
 
2.15 Zeta Potential 37
 
2.16 Rise of Nanopharmaceuticals 38
 
2.17 Nanopharmaceuticals Approval Regulations (FDA Rules & Regulations) 39
 
2.18 Conclusions and Prospects for the Future 40
 
References 41
 
3 Applications and Prospects of Nanopharmaceuticals Delivery 45
Hemant K. S. Yadav, Fejer Al mohammedawi and Rawan J. I. Abujarad
 
3.1 Introduction 45
 
3.2 Nanopharmaceuticals 46
 
3.3 Development of Nanopharmaceuticals 46
 
3.3.1 From Lab to the Marketplace 46
 
3.3.2 Techniques 47
 
3.3.3 Cost 47
 
3.3.4 Ethics 48
 
3.3.5 Nanopharmaceuticals Approval Regulations (FDA Rules & Regulations) 48
 
3.4 Clinical Applications of Nanotechnology 49
 
3.4.1 Diagnostic Applications 49
 
3.4.1.1 Detection 50
 
3.4.1.2 Protein Chips 50
 
3.4.1.3 Individual Target Probes 50
 
3.4.1.4 Nanotechnology as a Tool in Imaging 51
 
3.4.1.5 Sparse Cell Detection 51
 
3.4.2 Therapeutic Applications 51
 
3.4.2.1 Surfaces 51
 
3.4.2.2 Gene Delivery 51
 
3.4.2.3 Drug Delivery 52
 
3.4.2.4 Liposomes 52
 
3.4.2.5 Nanotechnology in Orthopedic Applications 52
 
3.4.2.6 Nanotechnology in Cardiac Therapy 53
 
3.4.2.7 Nanotechnology in Dental Care 53
 
3.4.2.8 Biomolecular Engineering 53
 
3.4.2.9 Biopharmaceuticals 53
 
3.5 Nanopharmaceuticals Delivery--Recent Applications 54
 
3.5.1 Nanoparticulate Systems for Vaccine 54
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About the author

Raj K. Keservani, MPharm, is an associate professor in the Faculty of B. Pharmacy, CSM Group of Institutions, Prayagraj, India. He has more than 12 years of academic (teaching) experience from various institutes in India in pharmaceutical education. He has published more than 30 peer-reviewed papers in the field of pharmaceutical sciences in national and international journals, 1 patent, 43 book chapters, three co-authored books, and 19 edited books. His research interests include nutraceutical and functional foods, novel drug delivery systems (NDDS), transdermal drug delivery/drug delivery, health science, cancer biology, and neurobiology. Rajesh Kumar Kesharwani, PhD, is an associate professor in the Department of Computer Application, Nehru Gram Bharati (Deemed to be University), Prayagraj, India. He has more than 11 years of research and 9 years of teaching experience in various institutes in India. He has authored more than 55 peer-reviewed articles, 24 book chapters, and 15 edited books. His research fields of interest are medical informatics, protein structure and function prediction, computer-aided drug designing, structural biology, drug delivery, cancer biology, nano-biotechnology, and biomedical sciences. Anil K. Sharma, M.Pharm., PhD, is an assistant professor (Pharmaceutics) at the School of Medical and Allied Sciences, GD Goenka University, Gurugram, India. He has experience of more than 13 years in academics. He has published 30 peer-reviewed papers in the field of pharmaceutical sciences in nationally and internationally reputed journals as well as 16 book chapters and 15 edited books. His research interests encompass nutraceutical and functional foods, novel drug delivery systems (NDDS), drug delivery, nanotechnology, health science/life science, and biology/cancer biology/neurobiology.

Summary

ADVANCES in NOVEL FORMULATIONS for DRUG DELIVERY

The 27 chapters describe novel strategies for drug/nutraceutical delivery and embrace the development of formulations with herbal ingredients, while also highlighting disease therapeutics.

Drug delivery technology has witnessed many advancements purported to cater to the customized needs of its ultimate beneficiaries--the patients. Today, dosage forms are not confined to conventional tablets, capsules, or injectables, but have evolved to cover novel drug carriers such as particulates, vesicles, and many others. Nanotechnological advancements have played a major role in this paradigm shift in ways of delivering active pharmaceutical ingredients.

A new dimension in the use of food as medicine has also gained prominence in recent years. A portmanteau of nutrition and pharmaceuticals is "nutraceuticals," also known as functional foods and dietary supplements. The technologies which were earlier included in drug delivery have been attempted for the delivery of nutraceuticals as well. Herbal actives have received increased attention due to their low risk-to-benefit ratio. The field of drug delivery is quite dynamic in nature, as witnessed by its evolution from conventional dosage forms to nanotechnology-assisted drug products. A variety of formulations via different drug delivery routes have been developed to treat/cure/mitigate diseases or disorders.

This book, comprising of 27 chapters, is a thorough compilation of information relevant to drug delivery systems with an emphasis on products based on nanotechnology.

Audience

Researchers, scientists, industry professionals, formulators and product developers, regulatory agencies in a variety of settings including novel drug delivery research laboratories, pharmaceutical, and pharmacy industries, biomedical sciences, food and nutraceuticals manufacturers, and nanotechnology.

Product details

• Authors: Keservani, Keservani, Raj K. Keservani, Raj K. (Csm Group of Institutions Keservani, Rajesh Kumar Kesharwani, Anil K. Sharma
• Assisted by: Anil K Sharma (Editor), Raj K. Keservani (Editor), Keservani Raj K. (Editor), Rajesh Kumar Kesharwani (Editor), Rajesh Kumar Kesharwani (Editor), Anil K. Sharma (Editor), Sharma Anil K. (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 12.06.2023
• EAN: 9781394166435
• ISBN: 978-1-394-16643-5
• No. of pages: 576
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Chemie, Nanotechnologie, Medizin, Pharmakologie, chemistry, Nanomedizin, Nanotechnology, Pharmacology & Pharmaceutical Medicine, Pharmakologie u. Pharmazeutische Medizin, Medical Science, Nanomedicine, Wirkstoffformulierung, Wirkstofftransport, Drug Formulation & Delivery