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Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

English · Paperback / Softback

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Description

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Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host's innate immune defence mechanisms.
In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

List of contents

Genetic Diversity in Mycobacterium tuberculosis.- DNA Metabolism in Mycobacterial Pathogenesis.- Molecular Biology of Drug Resistance in Mycobacterium tuberculosis.- Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations.- Getting Across the Cell Envelope: Mycobacterial Protein Secretion.- A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria.- Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes.- Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis.- Host-Pathogen Interactions During Mycobacterium tuberculosis Infections.

Summary

Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms.
In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Product details

Assisted by D McKinney (Editor), D McKinney (Editor), John D. McKinney (Editor), Jea Pieters (Editor), Jean Pieters (Editor)
Publisher Springer, Berlin
 
Languages English
Product format Paperback / Softback
Released 01.01.2016
 
EAN 9783662521427
ISBN 978-3-662-52142-7
No. of pages 245
Dimensions 155 mm x 14 mm x 235 mm
Weight 394 g
Illustrations VIII, 245 p. 22 illus., 11 illus. in color.
Series Current Topics in Microbiology and Immunology
Current Topics in Microbiology and Immunology
Subjects Natural sciences, medicine, IT, technology > Biology > Microbiology

B, Medical research, Immunology, Microbiology (non-medical), molecular biology, Pharmacology, Biomedical and Life Sciences, Medical Microbiology, Biomedical Research, Molecular Medicine, Genetics (non-medical), Microbial Genetics and Genomics, Microbial genomics, Microbial Genetics, Drug Resistance

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