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Klappentext Assuming minimum background knowledge! the book develops an understanding of the molecular function of drugs and how they interact with the body! before exploring drug discovery and development. It goes on to examine topical issues in applications of medicinal chemistry to novel drug design! to give a contemporary view of the field. Inhaltsverzeichnis 1. Drugs and drug targets: an overview; PART A: DRUG TARGETS: STRUCTURE AND FUNCTION; 2. Protein structure and function; 3. Enzymes: structure and function; 4. Receptors: structure and function; 5. Receptors and signal transduction; 6. Nucleic acids: structure and function; PART B: PHARMACODYNAMICS AND PHARMACOKINETICS; 7. Enzymes as drug targets; 8. Receptors as drug targets; 9. Nucleic acids as drug targets; 10. Other drug targets; 11. Pharmacokinetics and related topics; CASE STUDY 1: STATINS; PART C: DRUG DISCOVERY! DESIGN! AND DEVELOPMENT; 12. Drug discovery: finding a lead; 13. Drug design: optimizing target interactions; 14. Drug design: optimizing access to the target; 15. Getting the drug to market; CASE STUDY 2: THE DESIGN OF ACE INHIBITORS; CASE STUDY 3: ARTEMISININ AND RELATED ANTIMALARIAL DRUGS; CASE STUDY 4: THE DESIGN OF OXAMNIQUINE; PART D: TOOLS OF THE TRADE; 16. Combinatorial synthesis; 17. Computers in medicinal chemistry; 18. Quantitative structure-activity relationships (QSAR); CASE STUDY 5: DE NOVO DESIGN OF A THYMIDYLATE SYNTHASE INHIBITOR; CASE STUDY 6: DESIGN OF A SEROTONIN ANTAGONIST AS A POSSIBLE ANXIOLYTIC AGENT; PART E: SELECTED TOPICS IN MEDICINAL CHEMISTRY; 19. Antibacterial agents; 20. Antiviral agents; 21. Anticancer agents; 22. Cholinergics! anticholinergics! and anticholinesterases; 23. Drugs acting on the adrenergic nervous system; 24. The opium analgesics; 25. Anti-ulcer agents; CASE STUDY 7: DESIGN OF A NOVEL ANTIDEPRESSANT
