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Informationen zum Autor Mark Hallett, MD, Senior Investigator at National Institute of Neurological Disorders and Stroke (NINDS), Chief of the Medical Neurology Branch and Chief of Human Motor Control Section; Editor-in-Chief of Clinical Neurophysiology; Associate Editor of Brain. Werner Poewe, Chairman of the Department of Neurology at Medical University of Innsbruck; Editorial board member of Movement Disorder, Journal of Neurology, Journal of Neural Transmission, and Aktuelle Neurologie. Klappentext Over the past few decades, neurology has seen spectacular developments in diagnostic techniques, particularly in neuroimaging and molecular genetics, accompanied by an increasing number of effective therapies to treat neurological disease. This is particularly true for the field of movement disorders. Since the highly successful introduction of levodopa about 40 years ago, the therapeutic options for Parkinson's disease have grown exponentially, often making treatment decisions difficult.This is the only current book on movement disorders to emphasize treatment. The authors, experts in their field, have used evidence from randomized controlled clinical trials to develop practical recommendations for every day clinical practice, bringing their personal clinical acumen and therapeutic wisdom to the book.* Provides a comprehensive update on therapies for Parkinson's disease and other movement disorders* Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management* Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions* The expert guidance of recognised authorities will enable readers of this book to plan their patients' care with greater confidenceTherapeutics of Parkinson's Disease & Other Movement Disorders is essential reading for residents in clinical neurology, clinical research fellows in neurology and related disciplines, general neurologists, and movement disorder specialists, as well as those working in the pharmaceutical industry with an interest in movement disorders. Zusammenfassung * Comprehensive evidence-based overview of current therapies for PD and other movement disorders * Reviews basic neuropathology, mechanisms of neurodegeneration and principles of pharmacologic intervention. Inhaltsverzeichnis Preface ix Contributors xi Part I Parkinson's Disease and Parkinsonism 1 The Etiopathogenesis of Parkinson's Disease: Basic Mechanisms of Neurodegeneration 3 C. Warren Olanow and Kevin McNaught 2 Physiology of Parkinson's Disease 25 Shlomo Elias, Zvi Israel and Hagai Bergman 3 Pharmacology of Parkinson's Disease 37 Jonathan M. Brotchie 4 The Treatment of Early Parkinson's Disease 49 Olivier Rascol and Regina Katzenschlager 5 Treatment of Motor Complications in Advanced Parkinson's Disease 71 Susan H. Fox and Anthony E. Lang 6 Managing the Non-Motor Symptoms of Parkinson's Disease 91 Werner Poewe and Klaus Seppi 7 Surgery for Parkinson's Disease 121 Jens Volkmann 8 Future Cell- and Gene-Based Therapies for Parkinson's Disease 145 Tomas Björklund, Asuka Morizane, Deniz Kirik and Patrik Brundin 9 Parkinson-Plus Disorders 157 Martin Köllensperger and Gregor K. Wenning Part II Tremor Disorders 10 Essential Tremor 179 Rodger J. Elble 11 Other Tremor Disorders 193 Günther Deuschl Part III Dystonia, Cramps, and Spasms 12 Pathophysiology of Dystonia 205 Mark Hallett 13 General Management Approach to Dystonia 217 Cynthia L. Comella 14 Botulinum Toxin for Treatment of Dystonia 227 Dirk Dressler 15 Surgical Treatments of Dystoni...
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"This book can be strongly recommended and is an asset to libraries of both movement disorder specialists and general neurologists. Its logical structure, linking therapy with underlying pathophysiology, means that it will remain a useful reference even as new therapies inevitably emerge." ( The Lancet Neurology , July 2009)
