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Informationen zum Autor Theodore P. Rasmussen, PhD is an Associate Professor in the Department of Pharmaceutical Sciences at the University of Connecticut, a charter member of the school's Stem Cell Institute, and a founding member of the university's Institute for Systems Genomics. Klappentext With contributions from leaders in the field, this comprehensive text considers the in vitro uses of stem cells for the detection of compounds that pose risk of birth defects. In addition, this text describes approaches to elucidate cellular and molecular mechanisms involved in the birth defect causation. Also of interest, this book contains accounts of impacts upon endogenous stem cells in vivo that lead to dysfunction relevant for human health.Stem Cells in Birth Defects Research and Developmental Toxicology includes contributions from leading experts in the field to offer a unique perspective on the topic that considers both in vitro uses of stem cells as platforms for teratology, and also "stem cellopathies." Stem cellopathies are human developmental and degenerative disorders that are caused by harmful impacts to resident adult stem cells in vivo.The text's introduction provides an overview of basic stem cell function and applications and covers the uses of stem cells for in vitro assays to detect suspected teratogens. The expert authors include information on human "stem cellopathies," and review the most current technical innovations in stem cell bioassays. This important resource:* Contains important platforms and recent accounts of the state of stem cell research in the fields of toxicology and teratology* Offers information on both in vitro uses of stem cells as platforms for teratology and stem cellopathies* Contains a helpful guide for the pharmaceutical industry and safety and environmental authorities to validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives* Features chapters from leaders at the interface of stem cell research and applied scienceWritten for toxicologists, stem cell researchers, epigeneticists, teratologists, pharmaceutical scientists, developmental biologists, and neonatologists, Stem Cells in Birth Defects Research and Developmental Toxicology offers a guide aimed at improving human fetal safety and the understanding of human developmental and degenerative disorders. Zusammenfassung This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders.* Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology* Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies! which are in vivo developmental and degenerative disorders* Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives Inhaltsverzeichnis List of Contributors xiii Preface xix Part I Introduction and Overview 1 1 The Basics of Stem Cells and Their Utility as Platforms to Model Teratogen Action and Human Developmental and Degenerative Disorders 3 Bindu Prabhakar, Soowan Lee, and Theodore P. Rasmussen 1.1 Stem Cell Types and Basic Function 3 1.2 Pluripotency 6 1.2.1 Poised Chromatin of the Pluripotent Epigenome 6 1.2.2 Undirected Differentiation of Pluripotent Cells to Embryoid Bodies 7 1.2.3 Directed Differentiation of Pluripotent Cells 8 1.3 In vitro Uses of Pluripotent Cells 9 1.3.1 Pluripotent Cells for Toxicology 9 1.3.2 Pluripotent Cells for Teratology 11 1.3...
