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Informationen zum Autor Hitoshi Iba is a Professor in the Department of Information and Communication Engineering, Graduate School of Information Science and Technology, at the University of Tokyo, Tokyo, Japan. He is an Associate Editor of the IEEE Transactions on Evolutionary Computation and the Journal of Genetic Programming and Evolvable Machines. Nasimul Noman is a Lecturer in the School of Electrical Engineering and Computer Science at the University of Newcastle, NSW, Australia. From 2002 to 2012, he was a faculty member at the University of Dhaka, Bangladesh. Noman is an Editor of the BioMed Research International journal. His research interests include computational biology, synthetic biology, and bioinformatics. Klappentext Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRNs) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored by well-known researchers and experienced practitioners, provides the relevant materials for the interested readers. The first part of this book contains an introductory background to the field. The second part of this book presents the EC approaches for analysis and reconstruction of GRNs from gene expression data. The third part of this book covers the contemporary advancements in the automatic construction of gene regulatory and reaction networks, and gives direction and guidelines for future research. Finally, the last part of this book focuses on applications of GRNs with EC in other fields, such as design, engineering, and robotics. Provides a reference for current and future research in gene regulatory networks (GRNs) using evolutionary computation (EC) Covers sub-domains of GRN research using EC, such as expression profile analysis, reverse engineering, GRN evolution, and applications Contains useful contents for courses in GRNs, systems biology, computational biology, and synthetic biology Delivers state-of-the-art research in genetic algorithms, genetic programming, and swarm intelligence Evolutionary Computation in Gene Regulatory Network Research is a reference for researchers and professionals in computer science, systems biology, and bioinformatics, as well as for upper undergraduate, graduate, and postgraduate students. Zusammenfassung Introducing a handbook for gene regulatory network research using evolutionary computation! with applications for computer scientists! computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). Inhaltsverzeichnis Preface ix Acknowledgments xiii Contributors xv I Preliminaries 1 A Brief Introduction to Evolutionary and other Nature-Inspired Algorithms 3 Nasimul Noman and Hitoshi Iba 2 Mathematical Models and Computational Methods for Inference of Genetic Networks 30 Tatsuya Akutsu 3 Gene Regulatory Networks: Real Data Sources and Their Analysis 49 Yuji Zhang II EAs for Gene Expression Data Analysis and GRN Reconstruction 4 Biclustering Analysis of Gene Expression Data Using Evolutionary Algorithms 69 Alan Wee-Chung Liew 5 Inference of Vohradský's Models of Genetic Networks Using a Real-Coded Genetic Algorithm 96 Shuhei Kimura 6 GPU-Powered Evolutionary Design of Mass-Action-Based Models of Gene Regulation 118 Marco S. Nobile, Davide Cipolla, Paolo Cazzaniga and Daniela Besozzi 7 Modeling Dynamic Gene Expression in <...
