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Informationen zum Autor Peter J. H. Scott is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School (USA), Director of the University of Michigan PET Center (USA) and a member of the Interdepartmental Program in Medicinal Chemistry. Professor Scott edited Linker Strategies in Solid-Phase Organic Synthesis (also from Wiley) and is the series editor for both the Wiley Series on Radiochemical Syntheses and the Wiley Series on Solid Phase Organic Syntheses. Klappentext This book describes methods and procedures for preparing PET radiopharmaceuticals, and highlights new methods for conducting radiochemical reactions with carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in positron emission tomography (PET) imaging.* Provides reliable methods for radiochemical syntheses and reactions, including all essential information to duplicate the procedure* Eliminates the time-consuming process of searching journal articles and extracting pertinent details from lengthy experimental sections or supporting information* Focuses on an emerging and important area for pharmaceutical and medical applications* Encompasses technical, regulatory, and application aspects* Includes solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control Zusammenfassung This book provides reliable methods, including information to duplicate procedures, for synthesizing radiopharmaceuticals used in positron emission tomography (PET) imaging and saves chemists time by eliminating the time-consuming process of searching journal articles and extracting details from lengthy experimental sections. Inhaltsverzeichnis Contributors xi Editorial Preface xvii Abbreviations xix PART I FLUORINE-18 LABELED RADIOPHARMACEUTICALS 1 1. Synthesis of (¿)-[18F]Flubatine ([18F]FLBT) 3 Megan N. Stewart, Brian G. Hockley, and Peter J. H. Scott 2. Synthesis of [18F]-(¿)Fluoroethoxy Benzovesamicol ([18F]FEOBV) 13 Brian G. Hockley, Megan N. Stewart, and Peter J. H. Scott 3. Synthesis of [18F]Fluoromethylcholine ([18F]FCH) via [18F]Fluoromethyl Tosylate 21 Melissa E. Rodnick, Allen F. Brooks, Brian G. Hockley, Bradford D. Henderson, and Peter J. H. Scott 4. Radiosynthesis of [18F]Flotegatide ([18F]RGD-K5) 29 Hartmuth C. Kolb, Fanrong Mu, Umesh Gangadharmath, Vani P. Mocharla, Zhihong Zhu, Ashok Chaudhary, and Joseph C. Walsh 5. Synthesis of 3-[18F]Fluoro-5-(2-Pyridinylethynyl) Benzonitrile ([18F]FPEB) 41 Steven H. Liang, Daniel L. Yokell, Raul N. Jackson, Peter A. Rice, Eli Livni, David Alagille, Gilles Tamagnan, Thomas Lee Collier, and Neil Vasdev 6. Radiosynthesis of 2¿-Deoxy-2¿-[18F]Fluoro-5-Methyl-1-ß-d-Arabinofuranosyluracil ([18F]FMAU) 53 Kai Chen and Peter S. Conti PART II CARBON-11 LABELED RADIOPHARMACEUTICALS 63 7. Synthesis of N-[11C]Methyl-4-Piperidinyl Propionate ([11C]PMP) 65 Xia Shao and Peter J. H. Scott 8. Synthesis of 1-(2,4-Dichlorophenyl)-4-Cyano-5-(4-[11C]methoxyphenyl)-N-(Piperidin-1-yl)-1H-Pyrazole-3-Carboxamide ([11C]OMAR) 73 Xia Shao, Keunsam Jang, and Peter J. H. Scott 9. Synthesis of Carbon-11 Labeled (+)-4-Propyl-3,4,4a,5,6,10b-Hexahydro-2H-Naphtho[1,2-b][1,4]Oxazin-9-Ol ([11C]-(+)-PHNO) 81 Christophe Plisson, Joaquim Ramada-Magalhaes, and Jan Passchier 10. Synthesis of (R)-[N-Methyl-11C]PK11195 93 Vítor H. Alves, Antero J. Abrunhosa, and Miguel Castelo-Branco PART III OTHER RADIOPHARMACEUTICALS 103 11. Synthesis of Oxygen-15 Water ([15O]H2O) 105 David W. Dick and G. Leonard Watkins PART IV NEW METHODS FOR THE SYNTHESIS AND QUALITY CONTROL OF...
