Antifolate Drugs in Cancer Therapy

In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors,
5-fluorouracil, and the new generation of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. In addition, they review in depth the modulation of antifolate drugs, folate and antifolate transport mechanisms, polyglutamation, resistance, and drug combinations, as well as pharmacogenomics, pharmacodynamics, regulation of gene expression, and mechanisms of cell death.

The wide and progressive scope of Antifolate Drugs in Cancer Therapy provides entré to exciting new avenues for future research, and constitutes a new standard reference for all basic scientists and clinicians engaged in cancer therapeutics.

Dettagli sul prodotto

• Con la collaborazione di: An L Jackman (Editore), Ann L Jackman (Editore), Ann L. Jackman (Editore)
• Editore: Springer, Berlin
• Lingue: Inglese
• Contenuto: Libro
• Forma del prodotto: Tascabile
• Data pubblicazione: 22.04.2014
• Categoria: Scienze naturali, medicina, informatica, tecnica > Medicina > Farmacia
• EAN: 9781475745214
• ISBN: 978-1-4757-4521-4
• Numero di pagine: 456
• Illustrazioni: X, 456 p. 13 illus.
• Dimensioni (della confezione): 18.1 x 2.7 x 24.5 cm
• Peso (della confezione): 891 g
• Serie: Humana Press; Cancer Drug Discovery and Development; Cancer Drug Discovery and Development
• Categorie: Pharmazie, Apotheke, Pharmakologie, MEDICAL / Pharmacy, Arznei / Arzneimittellehre, Apotheke - Apotheker, Onkologie - Radioonkologie, Krebs (Krankheit) / Onkologie, C; SCF00008 - Pharmacy; SUCO11650 - Medicine