Endocrine Disrupters - Hazard Testing and Assessment Methods

Informationen zum Autor PETER MATTHIESSEN, PhD, is an aquatic ecotoxicologist who works as an independent consultant. Specializing in the study of endocrine disrupters, he has conducted extensive research into how sewage effluents cause feminization in wild male fish as well as how tributyltin-based antifoulants cause masculinization in wild female mollusks. Professor Matthiessen is a member of the UK Advisory Committee on Pesticides and Co-chair of the OECD Validation Management Group for Ecotoxicity Tests. He has contributed to the development of standardized ecotoxicity assays with sensitivity for endocrine disrupters as well as written guidance for the interpretation of the resulting data. Klappentext Enables researchers to assess the effects of endocrine disrupters as well as comply with new environmental regulationsEndocrine disrupters are chemicals-both man-made and natural-that interfere with the body's endocrine system, potentially resulting in adverse developmental, reproductive, neurological, and immune effects. In recent years, a number of regulatory authorities around the world have drafted or enacted legislation that requires the detection and assessment of the effects of endocrine disrupters on both humans and wildlife. In response, this book provides comprehensive, up-to-date information on the latest tested and proven methods used to detect and assess the environmental hazards posed by endocrine-disrupting chemicals.Endocrine Disrupters is divided into chapters covering each major taxon as well as chapters dedicated to hazard assessment and regulation. The book covers testing methods for all the vertebrate groups and several invertebrate phyla, including:* Crustaceans and mollusks* Insects* Fish* Amphibians and reptiles* Birds and mammalsMoreover, the book emphasizes practical, ethical testing methods that combine sensitivity, efficiency, statistical power, and reasonable cost.Each chapter is written by one or more international experts in ecotoxicology, offering readers step-by-step guidance for implementing each method based on the latest research and the authors' firsthand laboratory experience. Furthermore, all the chapters have been subjected to a rigorous peer review and edited in light of the reviewers' comments. References at the end of each chapter guide readers to the literature in the field.Endocrine Disrupters is recommended for scientists who need to test chemicals for possible endocrine-disrupting properties. It is also recommended for regulatory authorities who need to decide whether particular chemicals can be safely marketed. Zusammenfassung This book describes methodology and applications for endocrine disrupter toxicity testing, an issue of considerable urgency, because of international regulatory authorities currently considering such testing schemes. Inhaltsverzeichnis Preface ix Contributors xi 1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals: An Introduction 1 Peter Matthiessen 1.1 Background 1 1.2 Regulatory Concerns 2 1.3 Invertebrates 2 1.4 Vertebrates 3 1.5 Testing Schemes for EDCs 5 Reference 6 2 Endocrine Disruption inWildlife: Background, Effects, and Implications 7 Dick Vethaak and Juliette Legler 2.1 Background to Endocrine Disruption 8 2.2 Effects of EDCs on Wildlife 19 2.3 Weight of Evidence and Ecological Significance of ED Effects 32 2.4 Implications for Effect Assessment and Toxicity Testing 36 2.5 Need for More Field Studies and an Integrated Approach 38 2.6 Concluding Points 39 References 40 3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards toWildlife 59 Hans-Christian Stolzenberg, Tobias Frische, Vicki L. Dellarco, Gary Timm, Anne Gourmelon, Taisen Iguchi, Flemming Ingerslev, and Mike Roberts <...

Dettagli sul prodotto

• Autori: Matthiessen, P Matthiessen, Peter Matthiessen, Matthiessen Peter
• Con la collaborazione di: Peter Matthiessen (Editore)
• Editore: Wiley, John and Sons Ltd
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 22.03.2013
• EAN: 9780470932094
• ISBN: 978-0-470-93209-4
• Pagine: 416
• Categoria: Scienze naturali, medicina, informatica, tecnica > Chimica > Altro