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Klappentext * Contains chapters from recognized experts in phagocyte behavior that explore and explain the complex biology behind the roles fulfilled by different phagocyte linages* Discusses the different cell types, and how they sense and respond to their environment* Explores the properties and function of the phagosome itself, which is linked intimately with the divergent roles fulfilled by the professional phagocyte lineages* Includes chapters that explore a variety of different infection models and how the phagocytes respond to control the infection and bolster protective immunityExplains the complex biology behind the roles fulfilled by different phagocyte linages. This book discusses the different cell types, and how they sense and respond to their environment. It explores the properties and function of the phagosome itself, which is linked with the divergent roles fulfilled by the professional phagocyte lineages. Table of Contents Foreword: What Would Darwin Have Said? Samuel C. Silverstein Part 1: Biology of the Professional Phagocyte 1. Neutrophils Forever Taco W. Kuijpers, Timo K. van den Berg, and Dirk Roos 2. Macrophages: Microbial Recognition and Response Annette Pluddemann and Siamon Gordon 3. Dendritic Cells and Their Tissue Microenvironment during Exposure to Pathogens A. Mortellaro, F. Granucci, M. Foti, and P. Ricciardi-Castagnoli Part 2: Membrane Receptors: Recognition, Adhesion, Phagocytosis, Chemotaxis, and Migration 4. Fc Receptors and Phagocytosis Steven Greenberg and Benjamin M. Dale 5. Chemokines and Phagocyte Trafficking Timothy J. Williams and Sara M. Rankin 6. Toll-Like Receptors Ricardo T. Gazzinelli, Kate Fitzgerald, and Douglas T. Golenbock 7. C-Type Lectins: Multifaceted Receptors in Phagocyte Biology Alessandra Cambi and Carl G. Figdor 8. Integrins on Phagocytes Wouter L. W. Hazenbos and Eric J. Brown 9. Intracytosolic Sensing of Pathogens: Nucleic Acid Receptors, NLRs, and the Associated Responses during Infections and Autoinflammatory Diseases Thomas Henry and Denise M. Monack 10. Phagocytes as a Source of the Fluid-Phase Pattern Recognition Receptor PTX3: Interplay between Cellular and Humoral Innate Immunity Alberto Mantovani, Barbara Bottazzi, Andrea Doni, and Giovanni Salvatori 11. Leukocyte Chemotaxis Ann Wheeler and Anne J. Ridley Part 3: Phagocytosis: Signaling, Cytoskeleton, and the Phagosome 12. Signaling for Phagocytosis Joel A. Swanson 13. Membrane Trafficking during Phagosome Formation and Maturation Gregory D. Fairn, Elena Gershenzon, and Sergio Grinstein 14. Acidification of Endosomes and Phagosomes Sushmita Mukherjee and Frederick R. Maxfield 15. Actin-Based Motility in Professional Phagocytes Frederick S. Southwick 16. Functional Analysis of the Intraphagosomal Environment of the Macrophage: Fluorogenic Reporters and the Transcriptional Responses of Salmonella and Mycobacterium Robin M. Yates, Kyle H. Rohde, Robert B. Abramovitch, and David G. Russell Part 4: Bridging the Gap between the Innate and Acquired Immune Response 17. Novel Anti-Inflammatory and Pro-Resolution Lipid Mediators in Induction and Modulation of Phagocyte Function Charles N. Serhan and Julio Aliberti 18. Cytokines and Macrophages and Dendritic Cells: Key Modulators of Immune Responses Frank Kaiser and Anne O'Garra 19. Macrophage Classical Activation Donald C. Vinh and Steven M. Holland 20. The Functional Heterogeneity of Activated Macrophages Xia Zhang and David M. Mosser 21. Recognition and Removal of Apoptotic Cells Peter M. Henson and Donna L. Bratton 22. Regulation and Antimicrobial Function of Inducible Nitric Oxide Synthase in Phagocytes Christian Bogdan Part 5: Pathogens of the Professional Phagocyte 23. The Multiple Interactions between Salmonella and Phagocytes Jessica A. Thompson and David W. Holden 24. Legionella, a Pathogen of Amoebae and Macrophages Michele S. Sw...
