Cryptic Enzymes and Moonlighting Proteins

Cryptic Enzymes and Moonlighting Proteins, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signaling cascades. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signaling, metabolic enzymes moonlighting as RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades.

The book also explores recent advances in research and brings together an array of information across different fields to enable better targeting of these exciting proteins and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, users will find examples of cryptic enzymes across species, as well as those in human healthy biology and pathogenesis.

Product details

• Assisted by: Gehring Chris (Editor), Aloysius Wong (Editor), Irving Helen (Editor)
• Publisher: Elsevier
• Content: Book
• Product form: Paperback / Softback
• Publication date: 18.06.2025
• Subject: Natural sciences, medicine, IT, technology > Biology > General, dictionaries
• EAN: 9780443157196
• ISBN: 978-0-443-15719-6
• Dimensions (packing): 19.1 x 23.5 cm
• Weight (packing): 810 g
• Series: Foundations and Frontiers in Enzymology
• Subjects: Calcium, Camp, machine learning, Genome, Channel, METABOLISM, SCIENCE / Life Sciences / Biochemistry, Database, SCIENCE / Life Sciences / Molecular Biology, SCIENCE / Life Sciences / Biophysics, biochemistry, molecular biology, bioinformatics, immune system, Mental disorder, mass spectrometry, CGMP, Proteomics, Biophysics, Cytokines, Plant biology, Enzymology, biomolecules, cell signaling, Phosphodiesterase, immunity, immune response, innate immunity, Phosphodiesterases, Crosstalk, Extracellular vesicles, gas sensing, Matrix Metalloproteinases, Intrinsic disorder, RNA binding proteins, nitric oxide, fluorescent tagging, Protein structure and function, heteroreceptor complexes, Plant (plant biology), G protein–coupled receptor, cyclic nucleotides, cyclase, moonlighting proteins, Anabolism, oligomerization, Auxin signaling, Properties of biomolecules, Cellular process, Experimental approach in biochemistry, protein function prediction, Adenylyl Cyclase, intermediary metabolism, Molecular network, Omics Data, Molecular mechanism of gene regulation, Function prediction, guanylate cyclase, H-NOX domain, Intramolecular signaling, Interleukin-1 receptor-associated kinase-3, Catalytic centers, Cyclic guanosine monophosphate, Adenylate cyclase (AC), H-NOX protein, Computational searches, Moonlighting protein, Phosphodiesterase (PDE), molecular interaction, E3 Ubiquitin Ligase, Biochemical mechanism, Growth differentiation factor 15, Heme-nitric oxide/oxygen binding domain, Nitric oxide sensing, multifunctional protein, Mitochondrial target signal, Dual function, Biology experimental methods, Signaling microenvironment, Immunogold staining, Cryptic nucleotide cyclase, Cryptic functional site, Cyclic adenosine monophosphate, Signal cascades, Regulation of translation, heat shock proteins, Cell signaling integration, Moonlighting enzymes, cyclic nucleotide, Adenylate cyclases, Extracellular vesicles cargo, Cryptic enzymes, Receptor kinases, Cryptic enzyme interactome, Crypto-AC, Aux/IAAs, Organelles localization signal, Protein–protein interactions (PPIs), Moonlighting domains, Guanylate cyclases, Moonlightning protein, Hemo protein, adenylate cyclase