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Informationen zum Autor Shinichi Itsuno, PhD , is a Professor at Toyohashi University of Technology. His research focuses on the interface between organic chemistry and polymer chemistry, and is especially concerned with asymmetric synthesis, reactive polymers, and new polymer synthesis. Dr. Itsuno has written over a hundred papers, as well as thirty book chapters. Klappentext Get to grips with chiral polymer synthesis and its application to asymmetric catalysis Written and edited by leading experts from around the world, Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis is the first book to bring together in a coherent and cohesive form the history and latest research on chiral polymers. Because they can be easily separated from a reaction mixture and reused, repeatedly, polymer-immobilized chiral catalysts have received considerable attention in recent years, making the book a particularly timely contribution to the literature on the subject. Covering polymer-immobilized catalysts, the design of polymer-immobilized asymmetric catalysts, the synthetic aspects of chiral polymers, and dendrimers, the book includes chapters on peptide-catalyzed and enantioselective synthesis,optically-active polymers, continuous flow processes, and much more. With up-to-the-minute explanations of potential applications in academic and industry R&D, Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis is an absolute must-have resource. Not only is it suitable for use as an introductory text for students, it also provides a much-needed one-stop handbook for professionals interested in the chemistry, properties, and applications of chiral polymers. Zusammenfassung This book reviews chiral polymer synthesis and its application to asymmetric catalysis. It features the design and use of polymer-immobilized catalysts and methods for their design and synthesis. Chapters cover peptide-catalyzed and enantioselective synthesis, optically-active polymers, and continuous flow processes. Inhaltsverzeichnis PREFACE xiii FOREWORD xvii CONTRIBUTORS xix 1 An Overview of Polymer-Immobilized Chiral Catalysts and Synthetic Chiral Polymers 1 Shinichi Itsuno 1.1 Introduction / 1 1.2 Polymeric Chiral Catalyst / 2 1.3 Synthesis of Optically Active Polymers / 8 2 Polymer-Immobilized Chiral Organocatalyst 17 Naoki Haraguchi and Shinichi Itsuno 2.1 Introduction / 17 2.2 Synthesis of Polymer-immobilized Chiral Organocatalyst / 18 2.3 Polymer-immobilized Cinchona Alkaloids / 22 2.4 Other Polymer-immobilized Chiral Basic Organocatalysts / 27 2.5 Polymer-immobilized Cinchona Alkaloid Quaternary Ammonium Salts / 28 2.6 Polymer-immobilized MacMillan Catalysts / 35 2.7 Polymer-immobilized Pyrrolidine Derivatives / 42 2.8 Other Polymer-immobilized Chiral Quaternary Ammonium Salts / 46 2.9 Polymer-immobilized Proline Derivatives / 46 2.10 Polymer-immobilized Peptides and Poly(amino acid)s / 50 2.11 Polymer-immobilized Chiral Acidic Organocatalysts / 50 2.12 Helical Polymers as Chiral Organocatalysts / 51 2.13 Cascade Reactions Using Polymer-immobilized Chiral Organocatalysts / 52 2.14 Conclusions / 54 3 Asymmetric Synthesis Using Polymer-Immobilized Proline Derivatives 63 Michelangelo Gruttadauria, Francesco Giacalone, and Renato Noto 3.1 Introduction / 63 3.2 Polymer-supported Proline / 66 3.3 Polymer-supported Prolinamides / 73 3.4 Polymer-supported Proline-Peptides / 75 3.5 Polymer-supported Pyrrolidines / 78 3.6 Polymer-supported Prolinol and Diarylprolinol Derivatives / 80 3.7 Conclusions and Outlooks / 84 4 Peptide-Catalyzed Asymmetric Synthesis 91 Kazuaki Kudo and Kengo Akagawa 4.1 ...
