Evolution of Translational Omics Lessons Learned and the Path Forward

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Product details

• Authors: Institute of Medicine, Board on Health Sciences Policy, Board on Health Care Services, Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
• Assisted by: Gilbert S Omenn (Editor), Sharly J Nass (Editor), Christine M Micheel (Editor)
• Publisher: National Academies Press
• Content: Book
• Product form: Paperback / Softback
• Publication date: 13.09.2012
• Subject: Natural sciences, medicine, IT, technology > Medicine > General
• EAN: 9780309224185
• ISBN: 978-0-309-22418-5
• Pages: 354
• Subjects: Science; SCIENCE / Life Sciences / Biochemistry; SCIENCE / Biotechnology; SCIENCE / Life Sciences / Genetics & Genomics; MEDICAL / Allied Health Services / Medical Technology