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A synthesis of the most up-to-date research and technologies in fertility preservation, written by leading experts in the field.
List of contents
Section 1 Introduction: 1. The evolution of the assisted reproduction technologies; 2. The effect of chemotherapy on the human reproductive system; 3. The effect of radiotherapy on the human reproductive system; 4. The need for fertility preservation in cancer patients; Section 2 Reproductive biology and cryobiology: 5. Life and death in the germ line: apoptosis and the origins of DNA damage in human spermatozooa; 6. Principles of vitrification as a method of cryopreservation in reproductive biology and medicine; Section 3 Fertility preservation in cancer and non-cancer patients: 7. Fertility preservation in non-cancer patients; 8. Fertility preservation in women with ovarian endometrioma: from surgery to oocyte and ovarian tissue freezing; 9. Pediatric cancer therapy and fertility; 10. Breast cancer therapy and fertility; 11. Fertility preservation in young adults with gastrointestinal and hematological malignancies; Section 4 Fertility preservation strategies in the male: 12. Transplantation of cryopreserved spermatogonia; 13. Cryopreservation and grafting of immature testicular tissue; 14. Use of cryopreserved sperm and ART after chemotherapy or radiotherapy; Section 5 Fertility preservation strategies in the female: medical/surgical: 15. Use of GnRH analogs for prevention of chemotherapy-induced gonadotoxicity; 16. Ovarian transposition before radiotherapy Yaron Gill and Togas Tulandi; 17. Fertility-saving surgery for gynaecological cancers; 18. Results of conservative management of ovarian malignant tumours; Section 6 Fertility preservation strategies in the female: ART: 19. Embryo cryopreservation as a fertility preservation strategy; 20. Vitrification of human oocytes as a fertility preservation strategy; 21. Autotransplantation of cryopreserved ovarian tissue: techniques and results; 22. ART and oocyte donation in cancer survivors; Section 7 Ovarian cryopreservation and transplantation: 23. Ovarian cryopreservation and transplantation: overview; 24. Cryopreservation of ovarian tissue by vitrification: techniques and results; 25. Ovarian tissue cryopreservation; 26. Risk of transplanting malignant cells in cryopreserved ovarian tissue; 27. Whole ovary freezing and transplantation; Section 8 In-vitro follicle culture: 28. Molecular and cellular integrity of cultured follicles; 29. In-vitro growth of human oocytes; 30. Contributions of ovarian stromal cells to follicle culture; 31. In-vitro maturation of germinal vesicle oocytes; 32. Survival of primordial follicles: tips and tricks; Section 9 New research and technologies: 33. The artificial ovary; 34. Uterus transplantation: research and clinical possibilities; 35. Ovarian allotransplantation; 36. Allotransplantation of human ovarian tissue; 37. Predicting ovarian futures: the contribution of genetics; Section 10 Ethical, legal and religious issues: 38. Fertility preservation: ethical considerations; 39. Legal issues of fertility preservation; 40. Christian ethics in fertility preservation.
About the author
Jacques Donnez is Professor Emeritus of the Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium.S. Samuel Kim is Professor (retired) of the Division of Reproductive Endocrinology, University of Kansas School of Medicine, Kansas, USA. He is also Director of Eden Centers for Advanced Fertility, California, USA.
Summary
Comprehensive new edition covering topics ranging from the effects of cancer treatment on fertility, to fertility preservation strategies in males and females, including cryopreservation and transplantation. A valuable reference for clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.
