Fr. 5,184.00

DJ Abraham, Donald J. Abraham, Michael Myers, Donald J. Abraham, Michael Myers

Burger s Medicinal Chemistry, Drug Discovery and Development, 8 - Volume Se

English · Hardback

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Description

Das wegweisende Referenzwerk für Medizinchemiker und Pharmazeuten wurde mit dieser Ausgabe umfassend aktualisiert und umfasst jetzt auch die Konzepte der Suche nach neuen Arzneimitteln neben dem gesamten Prozess der Entdeckung und Entwicklung von Arzneimitteln.

* Mit Themenbänden oder Kapiteln über die Entdeckung von Arzneimitteln, die Entwicklung von Arzneimitteln, Herz-Kreislauf-Erkrankungen, Stoffwechselerkrankungen, Immunologie, Krebs, Antiinfektiva und ZNS-Erkrankungen
* Die vorhandenen Kapitel wurden aktualisiert und um 35 neue ergänzt, insbesondere zu den Konzepten der Suche nach Arzneimitteln
* Das Werk umfasst u.a. die Themen: Behandlung von Opioidabhängigkeit, Antikörper- und Gentherapie gegen Krebs, Blut-Hirn-Schranke, HIV-Behandlung und Forschungsverbünde zwischen Industrie und Wissenschaft

List of contents

PREFACE OF THE EDITOR-IN-CHIEF

PREFACE OF THE CONSULTING EDITOR

PREFACE OF THE VOLUME EDITOR

CONTRIBUTORS

Volume 1 : Methods in Drug Discovery

1 Chirality and Drug Discovery

2 Drug Discovery beyond the Rule of Five

3 Microbes to Man: From Soils and the Depths to Drugs as of early 2019

4 Fragment-Based Lead Discovery

5 Recent Advances in Development, Validation, and Exploitation of QSAR Models

6 Structure-Based Drug Design

7 Docking, Scoring and Virtual Screening in Drug Discovery

8 Computational Chemistry Tools

9 Assay Development and High-Throughput Screening

10 Advances in NMR-based Characterization of Drug Substances, Impurities, Degradants and Drug Metabolites

11 NMR-Based Screening and Drug Discovery

12 Mass Spectrometry and Drug Discovery

13 Cryo Electron Microscopy in Drug Discovery and Development: Opportunities and Challenges

14 Combinatorial Chemistry and Its Associated Technologies

15 Recent Advances in Chemistry Technologies and Applications to Medicinal Chemistry

16 Automated Synthesis

17 Artificial Intelligence in Medicinal Chemistry

18 Medicinal Chemical Biology

Volume 2 : Lead Discovery in Drug Discovery

1 Ion Channels as Therapeutic Drug Targets

2 Drug Transport and Membrane Transport Proteins

3 Structure-Based Drug Design for G Protein-Coupled Receptors

4 Enzymes as Drug Targets

5 Allosterism & Drug Discovery

6 Nuclear Hormone Receptor Medicinal Chemistry

7 ADMET In Vitro Profiling Utility and Applications in Lead Discovery

8 Principles of Drug Metabolism

9 Advances in Multiobjective Optimization for Drug Discovery and Development

10 The Design and Application of Bioisosteres in Drug Design

11 Structure Alerts in Medicinal Chemistry (original chapter: Structural Alerts for Toxicity)

Volume 3 : Development

1 Intellectual Property for Biotechnology and Pharmaceutical Products

2 Experiences in Academic and Industry Partnerships Forging a Path to Translational Drug Discovery

3 Large-Scale Synthesis

4 Preparative Chromatography for Production

5 Translational Pharmaceutics and Early Phase Clinical Development

6 Salt Screening and Selection

7 Polymorphic Crystal Forms in Drug Delivery (Crystal Engineering)

8 Physicochemical Characterization and Oral Dosage Form Design and Selection

9 Prodrugs: Strategic Deployment, Metabolic Considerations, and Chemical Design Principles

10 Provisional BCS Classification of Leading Oral Drugs in Global Market

11 Process Development of Protein Therapeutics

12 Role of Permeability in Drug ADME, PK Interactions and Toxicity

13 Toxicology and Nonclinical Safety Assessment in Pharmaceutical Discovery and Development

14 Quality Assurance

15 The FDA and Drug Regulatory Issues

16 FDA-Approved Medicines

17 Clinical Development - A Primer

18 Global Health Outcomes and Real World Evidence a Primer

19 A Brief Primer on Project Leadership, Project Management and Cross-Functional Teams

Volume 4 : Cardiovascular, Endocrine and Metabolic Diseases

1 Dipeptidyl Peptidase 4 Inhibitors

2 Glucagon Like Peptide 1 Receptor Activators

3 Sodium Glucose Co-Transporter Inhibitors for the Treatment of Diabetes

4 Treatments for Non-Alcoholic Steatohepatitis (NASH)

5 Therapeutic Strategies for Sickle Cell Disease

6 Hematopoietic Agent

About the author

Donald J. Abraham is Emeritus Professor of Medicinal Chemistry and Emeritus Director of the Institute for Structural Biology and Drug Discovery at Virginia Commonwealth University. He is a member of the Hall of Fame of the American Chemical Society's Medicinal Chemistry Division.

Michael Myers, PhD is Senior Director of Due Diligence at Lilly Research Labs. He has worked in drug discovery and development for over 30 years. He holds over 35 patents and has led efforts in evaluating new lead generation technologies and processes in early drug discovery, predictive ADMET, and computational chemistry.

Kent D. Stewart, PhD (Volume Editor) is Associate Professor of Basic Pharmaceutical Sciences at High Point University. Previously, he worked for over 25 years in the industry at Burroughs Wellcome, AbbVie, and Abbott Laboratories.

Summary

Product details

Authors	DJ Abraham, Donald J. Abraham, Michael Myers
Assisted by	Donald J. Abraham (Editor), Michael Myers (Editor)
Publisher	Wiley, John and Sons Ltd

Languages	English
Product format	Hardback
Released	31.12.2020

EAN	9781119530305
ISBN	978-1-119-53030-5
No. of pages	6032
Series	Burger's Medicinal Chemistry, Drug Discovery and Development
Subjects	Natural sciences, medicine, IT, technology > Chemistry Chemie, Organische Chemie, Medizin, ORGANIC CHEMISTRY, chemistry, MEDIZINISCHE CHEMIE, Pharmacology & Pharmaceutical Medicine, Pharmakologie u. Pharmazeutische Medizin, Wirkstoffforschung u. -entwicklung, Drug Discovery & Development, Medical Science

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