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Informationen zum Autor Neal R. Cutler is the editor of Pharmacodynamics and Drug Development: Perspectives in Clinical Pharmacology, published by Wiley. John J. Sramek is the editor of Pharmacodynamics and Drug Development: Perspectives in Clinical Pharmacology, published by Wiley. Klappentext In recent years it has become clear that early information about pharmacodynamics leads to more efficient trial designs and improved clinical guidelines for the use of all drugs. Spanning many of the major drug classes, this book offers the essential facts and concepts and includes an authoritative section on general methodology and regulatory issues. The molecular biology and pharmacology of major receptor types are considered, as is the detailed pharmacodynamics of a wide range of therapeutic drug classes. The book will be of interest to researchers, clinical pharmacologists, physicians and regulators working in academia as well as the pharmaceutical industry worldwide. Zusammenfassung Spanning many of the major drug classes! this guide explores the key factors of drug development! concentrating on general methodology and regulatory issues. It considers the pharmacology of major receptor types and the pharmacodynamics of a wide range of therapeutic drug classes. Inhaltsverzeichnis Partial table of contents: OVERVIEW OF PHARMACODYNAMICS. Basic Pharmacodynamic Concepts and Models (R. Wills). Factors Influencing Variability in Kinetics and Dynamics (P. Narang& R. Li). General Perspectives on the Role of Metabolite in Pharmacokineticsand Pharmacodynamics (R. Seifert). Regulatory Perspective: The Role of Pharmacokinetics andPharmacodynamics (L. Lesko & R. Williams). APPLICATION OF PHARMACODYNAMICS IN SELECTED THERAPEUTICDOMAINS. Theoretical Models for Developing Anxiolytics (P. Nickell & T.Uhde). Pharmacodynamics of Antipsychotic Drugs in Schizophrenia (J. Sramek& G. Simpson). Antihypertensive Drugs (L. Prisant & A. Carr). Pharmacodynamics of Antineoplastic Agents (G. Rosner & M.Ratain). Virology and Antiviral Drug Development (M. Amantea, et al.). FRONTIERS IN PHARMACODYNAMICS: INSIGHT FROM MOLECULARAPPROACHES. Muscarinic Receptors: Pharmacological Subtypes, Structure, Functionand Regulation (L. Mei, et al.). Serotonin Receptor Subtypes (D. Pritchett). Index....
