Myeloid Cells in Health and Disease - A Synthesis

Klappentext The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells.In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including* the recruitment of myeloid and other immune cells following microbial infection* the role of myeloid cells in the inflammation process and the repair of damaged tissue* the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin* receptors and downstream signaling pathways that are activated following ligand-receptor binding* roles of myeloid cells during microbial and parasite infections* contributions of myeloid cells in atherosclerosis* myeloid-derived suppressor cells in tumor development and cancerMyeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies. Zusammenfassung The structure! functions! and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet! much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses! single-cell methods! gene editing! and modern imaging techniques to reveal new subclasses of differentiated myeloid cells! new receptors and cytokines! and important interactions among immune cells.In Myeloid Cells in Health and Disease: A Synthesis! Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich! Elie Metchnikoff! and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells! including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology! including* the recruitment of myeloid and other immune cells following microbial infection* the role of myeloid cells in the inflammation process and the repair of damaged tissue* the vast arsenal of myeloid cell secretory molecules! including metalloproteinases! tumor necrosis factor! histamine! and perforin* receptors and downstream signaling pathways that are activated following ligand-receptor binding* roles of myeloid cells during microbial and parasite infections* contributions of myeloid cells in atherosclerosis* myeloid-derived suppressor cells in tumor development and cancerMyeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology! hematology! microbial pathogenesis! infecti...

List of contents

Contributors
 
Preface
 
Acknowledgments
 
About the Editor
 
Section I Introduction and History
 
1 Paul Ehrlich and the Early History of Granulocytes
A. Barry Kay
 
2 The Phagocyte, Metchnikoff, and the Foundation of Immunology
Giuseppe Teti, Carmelo Biondo, and Concetta Beninati
 
3 Growth and Differentiation Factors
Donald Metcalf and Nicos A. Nicola
 
Section II General Aspects
 
4 Evolution of Myeloid Cells
Daniel R. Barreda, Harold R. Neely, and Martin F. Flajnik
 
5 Advances on Myeloid Like-Cell Origins and Functions in the Model Organism Drosophila melanogaster
Laure El Chamy, Nicolas Matt, and Jean-Marc Reichhart
 
6 Monocyte, Macrophage, and Dendritic Cell Development: the Human Perspective
Matthew Collin and Venetia Bigley
 
7 Myeloid Cell Turnover and Clearance
William J. Janssen, Donna L. Bratton, Claudia V. Jakubzick, and Peter M. Henson
 
Section III Specialization
 
8 Transcriptional Regulation and Macrophage Differentiation
David A. Hume, Kim M. Summers, and Michael Rehli
 
9 Murine Monocytes: Origins, Subsets, Fates, and Functions
Alexander Mildner, Goran Marinkovic, and Steffen Jung
 
10 Dendritic Cells in the Immune System--History, Lineages, Tissues, Tolerance, and Immunity
Jonathan M. Austyn
 
11 Antigen Processing and Presentation Mechanisms in Myeloid Cells
Paul A. Roche and Peter Cresswell
 
12 Microglia
V. Hugh Perry
 
13 Osteoclasts--Key Players in Skeletal Health and Disease
Deborah Veis Novack and Gabriel Mbalaviele
 
14 The Regulatory Function of Eosinophils
Ting Wen and Marc E. Rothenberg
 
Section IV Recruitment, Inflammation, and Repair
 
15 Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident Patrolling
Justin F. Deniset and Paul Kubes
 
16 Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity
Thomas A. Kufer, Giulia Nigro, and Philippe J. Sansonetti
 
17 Inflammasomes in Myeloid Cells: Warriors Within
Sushmita Jha and Jenny Pan-Yun Ting
 
18 Inflammation--a Critical Appreciation of the Role of Myeloid Cells
Asif J. Iqbal, Edward A. Fisher, and David R. Greaves
 
19 Lipid Mediators in Inflammation
Melanie Bennett and Derek W. Gilroy
 
20 Macrophage Proresolving Mediators--the When and Where
Jesmond Dalli and Charles Serhan
 
21 Myeloid Cells in Cutaneous Wound Repair
Jenna L. Cash and Paul Martin
 
Section V Recognition, Signaling, and Gene Expression
 
22 The Role and Function of Fcgamma Receptors on Myeloid Cells
Stylianos Bournazos, Taia T. Wang, and Jeffrey V. Ravetch
 
23 Complement Receptors in Myeloid Cell Adhesion and Phagocytosis
Michael L. Dustin
 
24 Toll-Like Receptor Signaling and Its Inducible Proteins
Takashi Satoh and Shizuo Akira
 
25 Lectin Receptors Expressed on Myeloid Cells
Gordon D. Brown and Paul R. Crocker
 
26 G Protein-Coupled Receptors in Macrophages
Hsi-Hsien Lin and Martin Stacey
 
27 Molecular Mechanisms of Phagosome Formation
Valentin Jaumouillé and Sergio Grinstein
 
28 Role of the Cytoskeleton in Myeloid Cell Function
Noah Fine, Samira Khaliq, Siavash Hassanpour, and Michael Glogauer
 
29 Coordinated Regulation of Signaling Pathways during Macrophage Activation
Toby Lawrence
 
30 Genome-Wide Approaches to Defining Macrophage Identity and Function
Gregory J. Fonseca, Jason S. Seidman, and Christopher K. Glass
 
31 Epigenetic Regulation of Myeloid Cells
Lionel B. Ivashkiv and Sung Ho Park
 
Section VI Secretion and Defense
 
32 Secretion from

Product details

• Authors: S Gordon, Siamon Gordon, Siamon (EDT) Gordon, Siamon Gordon
• Assisted by: Siamo Gordon (Editor), Siamon Gordon (Editor), Siamon (University of Oxford) Gordon (Editor)
• Publisher: American Society for Microbiology
• Languages: English
• Product format: Hardback
• Released: 31.05.2017
• EAN: 9781555819187
• ISBN: 978-1-55581-918-7
• No. of pages: 600
• Series: ASM Books; ASM
• Subjects: Natural sciences, medicine, IT, technology > Medicine; Mikrobiologie, Medizin, microbiology, Medical Science, Mikrobiologie u. Virologie, Myeloische Zellen