p53 in the Clinics

This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into the clinics. The goal of this book is to capture these developments and to appeal to a clinical and medical audience beyond the one which was the primary target of "25 years of p53".

List of contents

Foreword.- p53 activities and the hallmarks of cancer.- The inheritance of p53.- p53: Guardian of the metabolome.- The p53 family and stem cell biology.- Mutant p53-driven tumorigenesis.- Humanized p53 mouse models.- p53 models for mammary carcinogenesis.- TP53 somatic mutations: Prognostic and predictive value in human cancers.- Assessing TP53 status in human tumors - lessons from breast cancer.- TP53 germline mutations: Genetics of Li-Fraumeni Syndrome.- TP53 gene therapy.- Upstream targets in the p53 pathway.- p53-reactivating molecules as research tools and anti-cancer drugs.- Restoring mutant p53 activity.- p53-immunotherapy of cancer.- Designing p53 trials: a surgical oncologist view.- p53 in the clinic: a pathologist view.- p53 in genetic counseling.- Index.

Summary

This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into the clinics. The goal of this book is to capture these developments and to appeal to a clinical and medical audience beyond the one which was the primary target of "25 years of p53".

Product details

• Assisted by: Klas G Wiman (Editor), Pierre Hainaut (Editor), Magal Olivier (Editor), Magali Olivier (Editor), Klas G. Wiman (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2014
• EAN: 9781489992178
• ISBN: 978-1-4899-9217-8
• No. of pages: 358
• Dimensions: 153 mm x 22 mm x 232 mm
• Weight: 563 g
• Illustrations: X, 358 p.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; B, Pharmacology, Biomedical and Life Sciences, Cancer Research, Biomedical Research, Pharmacology/Toxicology