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Klappentext Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. Zusammenfassung Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. Part of the "Methods in Enzymology" series! this title covers subjects such Crystallography of serpins and serpin complexes! Serpins as hormone transporters! and Production of serpins using cell free systems. Inhaltsverzeichnis 1. Development of inhibitors of PAI-1 Daniel Lawrence 2. Kinetics of Serpin interactions with cofactors and proteases Steven Olson 3. Fluorescence Correlation Spectroscopy (FCS) or Single molecule FRET Anne Gershenson 4. Serpin-enzyme receptors (LRP) Dudley Strickland 5. Predicting serpin / protease interactions Jiangning Song 6. Serpins and autophagy David Perlmutter 7. Plant Serpins Tom Roberts 8. High throughput Drug discovery Bibek Gooptu 9. Use of mouse models to study maspin function Ming Zhang 10. The study of antitrypsin deficiency using animal models Jeffrey Teckman 11. Use of Mouse Models to study PAI-1 Paul Declerck 12. Production of serpins using cell free systems Clifford Luke 13. Studying serpin polymerisation in vitro James Huntington 14. Serpins and neural function Denis Monard 15. Probing serpin conformational change using mass spectrometry and related methods Patrick Wintrode 16. Studying Serpin conformational change Randy Read 17. Production of serpins in bacteria Mary Pearce 18. Inhibition of cysteine proteases by serpins Jan Potempa 19. Post transcriptional regulation of serpins Rob Medcalf 20. Serpins and the complement system Rob Pike & Lakshmi Wijeyewickrema 21. Serpins in Caenorhabditis elegans Stephen Pak & Gary Silverman 22. PEDF and angiogenesis Patricia Becerra 23. The Serpinb1 knockout mouse Charaf Benarafa 24. Biophysical approaches to studying serpin folding Steve Bottomley 25. TALS for studying the proteases inhibited by Serpins Chris Overall ...
