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Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors fills that gap, serving as the first two-part reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types - lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age- and gender-related trends are also discussed, as is the use of biomarkers for early detection.
List of contents
I. GENERAL APPLICATIONS1. Brain Metastasis from Solid Tumors2. The Role of Surgical Resection for Metastatic Brain Tumors3. Whole Brain Radiotherapy for Brain Metastases: Is the Therapeutic Window Enlarging?
II. NON-SMALL CELL LUNG CANCER4. Brain Metastasis in Patients with Non-Small Cell Lung Cancer: Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor5. Brain Metastasis from Non-Small Cell Lung Cancer: Use of Egfr and Her-2 Status for Targeted Therapy6. Brain Metastases from Non-Small Cell Lung Cancer: Current Evidence in Management Using Tyrosine Kinase Inhibitor and Whole Brain Radiation Therapy7. Brain Metastasis in Patients with Non-Small Cell Lung Cancer: Immunohistochemical Markers
III. BREAST CANCER8. Brain Metastasis from Breast Cancer: Molecular Mechanisms9. New Targeted Therapies for Brain Metastasis from Breast and Lung Cancer and Melanoma10. Breast Cancers with Brain Metastases
IV. MELANOMA11. Brain Metastases in Melanoma Patients: Treatment with Adjuvant Postoperative Whole Brain Radiotherapy12. Melanoma Progression in the Brain: Role of Pericytes, the Basal Lamina, and Endothelial Cells in Tumor Vascularization
V. ESOPHAGEAL CANCER13. Brain Metastases from Esophageal Cancer in the Presence of Her-2 Overexpression
VI. RENAL CARCINOMA14. Brain Metastasis from Renal Carcinoma: Locoregional and Systemic Treatments
VII. GASTROINTESTINAL CANCER15. Gastrointestinal Cancer and Brain Metastasis Outcomes and Management
VIII. COLORECTAL CANCER16. Brain Metastasis of Colorectal Cancer: Microenvironment and Molecular Mechanism
IX. NASOPHARYNGEAL CARCINOMA17. Brain Metastasis from Nasopharyngeal Carcinoma
About the author
Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.
Summary
volume 1. Epidemiology, biology, and therapy
