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This symposium is devoted to Biotechnology in Blood Transfusion; there are 22 experts discussing the state of the art in the application of monoclonal anti bodies, recombinant DNA technologies and heterologous expression systems to the improvement and sometimes replacement of blood products, charac terization of blood constituents, and the effect of these developments on blood transfusion procedures. Ten and maybe five years ago the title of a symposium such as this would have been Biosciences in blood transfusion, informing what basic developments in molecular biology, biochemistry and human physiology might pertain to blood transfusion in the distant future. That future is getting closer, and not only one is interested in basic developments in immunology, recognition and identification of viral and bacterial components and products, tissue and blood bloodgroup blood group typing, typing, but also in the potential application of these developments and their economic perspectives. That is what biotechnology is all alI about: basic science telIs tells us where and how we might look for new technologies, and the development of such tech nologies is only possible if there is a perspective for improvement in quality, safety, acceptance or performance to cost ratio.
List of contents
I. Fundamentals of biotechnology.- Opportunities for biotechnology in transfusion medicine.- to molecular genetics and recombinant DNA technology.- Molecular genetic analysis of HLA class II polymorphism.- Bioengineering in blood transfusion medicine.- Discussion.- II. Laboratory application of biotechnology.- Biotechnology in glood group serology - Application and trends for the future.- The characterization of monoclonal antibodies directed against carbohydrate epitopes by immunochemical means; the importance of such monoclonal antibodies for the recognition of blood group antigens.- Biochemistry of HLA-B27 in transfected cells and transgenic mice.- Biotechnology in the development of HIV diagnostic procedures.- Biotechnology and the development of HBV diagnostic procedures.- Monoclonal antibodies in blood coagulation.- Discussion.- III. Biotechnology and blood components.- Monoclonal antibodies in the production of purified proteins from human plasma.- Production of clotting factors through biotechnology.- Mammalian cell expression and characterization of recombinant human antitrhombin III.- Production and testing of rDNA hepatitis B vaccine.- Production and application of monoclonal antibodies in T-cell depletion of bone marrow for transplantation.- LAK cell production: Application of rDNA and cell culture technology.- Biotechnology of hemopoietic cells in culture.- Discussion.- IV. Clinical application and future directions.- Use of gene probes for carrier detection and prenatal diagnosis in hemophillia A.- In vivo characteristics of rDNA Factor VIII: The impact for the future in hemophilia care.- Clinical experience with monoclate®, a monoclonal antibody purified Factor VIII preparation from human plasma.- Depletion of lymphocytes from bone marrow -indications, expectations and clinical experience.- Hematopoietic hormones in transfusion medicine.- Discussion.
Summary
Proceedings of the Twelfth Annual Symposium on Blood Transfusion, Groningen 1987, organized by the Red Cross Blood Bank, Groningen-Drenthe
