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Having been a fairly dormant specialty for many decades, in recent years there has been a remarkable increase in activity in Neuro-oncology from basic science through to the clinics. Reflecting this there have been considerable advancements in the understanding of the biology of CNS malignancies which have infirmed the development of many novel and successful therapies. This work aims to bring together the scattered literature on the new concepts in neuro-oncology for the benefit of those in the field. The book moves from concepts in the scientific basis of neuro-oncology, through to modelling techniques and finishing on the translation into clinical practice. Neuro-Oncology is one of the most exciting and rapidly evolving areas of oncology. In recent years there has been a remarkable increase in activity in the field, from basic science through to the clinic. This is reflected by advances in the understanding of the biology of CNS malignancies which have informed the development of novel and successful therapies. In this environment it is essential to facilitate communication and understanding of new ideas and concepts.
Emerging Concepts in Neuro-oncology is written with this in mind: to encourage collaboration across traditional boundaries and promote translational research for patient benefit. The book moves from concepts in the scientific basis of neuro-oncology in part one, through models of brain cancer in part two, to emerging concepts in clinical practice in part three, with a focus on translational research.
This book will be an essential read for neuroscience researchers, cancer researchers, neurosurgeons and clinical oncologists as well as anyone with an interest in this exciting, dynamic field.
List of contents
Part I Scientific Foundations
1. Classification of Gliomas
Pieter Wesseling
2. Epigenetics and Brain Cancer
Davide Sciuscio and Monika E. Hegi
3. Astrocyte Differentiation from Oligodendrocyte Precursors
Akiko Nishiyama
4. Stem Cells and Brain Cancer
Sara G.M. Piccirillo
Part II Models of Brain Cancer
5. In Vitro Models of Brain Cancer
David J. Ryan and Colin Watts
6. Mouse Models of Glioma Pathogenesis: History and State of the Art
Sebastian Brandner
7. The Application of Novel Ionising Radiation Species for Glioblastoma
Raj Jena
8. Advances in Imaging Brain Cancer
Stephen J. Price and Adam D. Waldman
Part III Emerging Concepts in Clinical Practice
9. Surgical Management of Glial Cancers
Walter Stummer
10. Radiation Oncology in Brain Cancer
Susan C. Short
11. Managing the Elderly Patient
Anthony J. Chalmers and Kathryn Graham
12. Brain Tumour Presentation in Children and Young People
David A. Walker and Sophie Wilne
13. How Can We Improve Clinical Trial Recruitment in Neuro-Oncology?
Sarah Jefferies
About the author
Colin Watts is a Clinician Scientist and Honorary Consultant Neurosurgeon at the Department of Clinical Neurosciences, Cambridge Centre for Brain Repair and Neurosurgery Unit, Cambridge University.
Summary
Having been a fairly dormant specialty for many decades, in recent years there has been a remarkable increase in activity in Neuro-oncology from basic science through to the clinics. Reflecting this there have been considerable advancements in the understanding of the biology of CNS malignancies which have infirmed the development of many novel and successful therapies. This work aims to bring together the scattered literature on the new concepts in neuro-oncology for the benefit of those in the field. The book moves from concepts in the scientific basis of neuro-oncology, through to modelling techniques and finishing on the translation into clinical practice.
Report
From the book reviews:
"This is an up to date reference on the surgical, chemotherapy, and radiosurgery of gliomas, both low and high grade neoplasms. ... I highly recommend this book for neurosurgeons, oncologists, radiation researchers, fellows and students." (Joseph J. Grenier, Amazon.com, October, 2014)
"In this book, the authors aim to comprehensibly describe new findings, as well as established facts, and to discuss their influence on current and possible future therapies. ... this is a well written book on current advances in the field of neuro-oncology. It is worth reading for basic researchers working in the field of neuro-oncology, as well as neuro-oncologists and neurosurgeons." (Anne-Katrin Hickmann, Innovative Neurosurgery, Vol. 1 (1), 2013)
