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Informationen zum Autor Jan Lötvall , Professor, Head of Department, EAACI, Secretary-General, co-Editor-in-Chief Respiratory Research, Department of Respiratory Medicine and Allergology , Göteborg University, Göteborg, SWEDEN Klappentext Advances in Combination Therapy for Asthma and COPD is a comprehensive review of the spectrum of agents currently available for treatment of asthma, COPD and other airway diseases and covers practical guidelines as well as challenges and complications in their use.This volume provides specialists in respiratory medicine the most up to date information on the agents and discusses how they might be deployed in combination. Possible complications of combination therapy are explored, including unforeseen drug interactions and adverse patient reactions. This valuable reference discusses the complexity of determining correct dosages when the possibility of a synergistic cross-reaction between the drugs may mean that the effect of the drugs prescribed could be enhanced when administered in combination, compared with when they are prescribed alone.Postgraduate and professional specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research can depend on this carefully crafted guide for authoritative information. Zusammenfassung Aimed at specialists in respiratory medicine, this new book comprehensively reviews the variety of agents currently available for treatment of asthma, COPD, and other airway diseases and covers practical guidelines as well as challenges and complications in their use. Inhaltsverzeichnis Contributors xi Preface xiii 1 Similarities and differences in the pathophysiology of asthma and COPD 1 J. Christian Virchow 1.1 Introduction 1 1.2 Pulmonary function abnormalities in asthma and COPD 3 1.3 Risk factors for asthma and COPD 5 1.4 Cellular inflammation in asthma and COPD 8 1.5 Distribution and consequences of inflammation in asthma and COPD 9 1.6 Patterns of epithelial injury in asthma and COPD 10 1.7 Airway hyperresponsiveness 10 1.8 Beta-receptor blockers 10 1.9 Differential diagnosis of asthma and COPD 11 1.10 Overlap syndrome 12 1.11 Conclusion 12 References 13 2 Glucocorticoids: pharmacology and mechanisms 16 Peter J. Barnes 2.1 Introduction 16 2.2 Chemical structures 16 2.3 The molecular basis of inflammation 17 2.4 Cellular effects of glucocorticoids 19 2.5 Glucocorticoid receptors 20 2.6 Glucocorticoid activation of gene transcription 22 2.7 Suppression of inflammatory genes 23 2.8 Steroid resistance 29 2.9 Interaction with 2-adrenergic receptors 32 2.10 Conclusions 33 References 33 3 Inhaled corticosteroids: clinical effects in asthma and COPD 38 Paul M. O'Byrne and Desmond M. Murphy 3.1 Introduction 38 3.2 Anti-inflammatory activity of corticosteroids 38 3.3 Routes of administration 39 3.4 Absorption and fate of corticosteroids 41 3.5 Currently available inhaled corticosteroids 41 3.6 Efficacy in asthma 43 3.7 Efficacy in COPD 44 3.8 Side effects of ICS 46 3.9 Conclusions 49 References 49 4 LABAs: pharmacology, mechanisms and interaction with anti-inflammatory treatments 53 Gary P. Anderson 4.1 Galenical forms of LABAs: formulations, isomers, enantiomers, diasteriomers and salts 55 4.2 Absolute and functional 2-adrenoceptor selectivity 56 4.3 Cellular organization of receptor clusters: functional structure of the 2-adrenoceptor and mode of signalling 58 4.4 Dimers and oligomers: homo- and heterodimerism/oligoism 60 4.5 Pharmacogenomics of the 2-adrenoceptor and adenylate cyclase polymorphism in rel...
