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This cutting-edge volume provides the very latest results of basic research in cell replication, often with a view to potential medical applications, especially new anti-proliferative cancer therapies. The book focuses on intracellular communication - the key to cell division, and hence to the inhibition of division of malignant cells - in terms of such highly evolved mechanisms as cyclin dependent kinases (cdk's). Contributors also examine DNA replication by way of so-called licensing factors, as well as the role of genes such as p53, known as the tumor suppressor gene. Other chapters painstakingly sift out "peripheral" agents such as cdk5 and cdk8.
Sommario
A quest for cytoplasmic factors that control the cell cycle.- G1/S regulatory mechanisms from yeast to man.- Regulation of G1 progression in fission yeast by the rum1+gene product.- Progression through G1 and S phases of adult rat hepatocytes.- A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry.- The plant cell cycle: conserved and unique features in mitotic control.- The functions of Myc in cell cycle progression and apoptosis.- DNA replication licensing factor.- Tyrosine kinases weel and mikl as effectors of DNA replication checkpoint control.- Regulation of Cdc2 activity by phosphorylation at T14/Y15.- The family of polo-like kinases.- Ubiquitin-dependent proteolysis and cell cycle control in yeast.- Suc1: cdc2 affinity reagent or essential cdk adaptor protein?.- Structural basis for chemical inhibition of CDK2.- Apoptosis and the cell cycle.- DNA damage checkpoints: Implications for cancer therapy.- Cellular responses to antimetabolite anticancer agents: cytostasis versus cytotoxicity.- Telomeres, telomerase, and the cell cycle.- The cyclin C/Cdk8 kinase.- Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators.- Role of Ca++/Calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.- The roles of DNA topoisomerase II during the cell cycle.- Orcadian rhythm of cell division.- The mammalian Golgi apparatus during M-phase.- Contributors.
